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Volume 26, Number 11—November 2020
Dispatch

Multiple Introductions of Salmonella enterica Serovar Typhi H58 with Reduced Fluoroquinolone Susceptibility into Chile

Mailis Maes1Comments to Author , Zoe A. Dyson1, Ellen E. Higginson, Alda Fernandez, Pamela Araya, Sharon M. Tennant, Stephen Baker, Rosanna Lagos, Myron M. Levine, Juan Carlos Hormazabal2, and Gordon Dougan2
Author affiliations: University of Cambridge, Cambridge, UK (M. Maes, Z.A. Dyson, E.E. Higginson, S. Baker, G. Dougan); Monash University, Melbourne, Victoria, Australia (Z.A. Dyson); London School of Hygiene & Tropical Medicine, London, UK (Z.A. Dyson); Instituto de Salud Publica de Chile, Santiago, Chile (A. Fernandez, P. Araya, J.C. Hormazabal); University of Maryland School of Medicine, Baltimore, Maryland, USA (S.M. Tennant, M. M. Levine); Hospital de Niños de Santiago, Santiago, Chile (R. Lagos)

Main Article

Figure 2

Nearest-neighbor calculations of Salmonella enterica serovar Typhi of genotype 4.3.1 and maximum-likelihood phylogenetic trees for 3 introductions of Salmonella Typhi genotype 4.3.1 into Chile in the context of their closest Salmonella Typhi isolate neighbors. A) Isolate collected during 2012–2014 resembles isolates from South Asia. B) Isolate collected during 2015 resembles isolates from India. C) Isolate collected in 2016 is closely related to a cluster of sequences from India and Bangladesh. Accession numbers, genotypes, countries, and years of isolation are shown. Stars indicate mutations in the quinolone resistance determining region of genes gyrA, gyrA-S83F and gyrA-D87N, and parC-S80I. Scale bars indicate SNP distance. SNP, single-nucleotide polymorphism.

Figure 2. Nearest-neighbor calculations of Salmonella enterica serovar Typhi of genotype 4.3.1 and maximum-likelihood phylogenetic trees for 3 introductions of Salmonella Typhi genotype 4.3.1 into Chile in the context of their closest Salmonella Typhi isolate neighbors. A) Isolate collected during 2012–2014 resembles isolates from South Asia. B) Isolate collected during 2015 resembles isolates from India. C) Isolate collected in 2016 is closely related to a cluster of sequences from India and Bangladesh. Accession numbers, genotypes, countries, and years of isolation are shown. Stars indicate mutations in the quinolone resistance determining region of genes gyrA, gyrA-S83F and gyrA-D87N, and parC-S80I. Scale bars indicate SNP distance. SNP, single-nucleotide polymorphism.

Main Article

1These first authors contributed equally to this work.

2These authors contributed equally to this work.

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