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Volume 26, Number 3—March 2020
Research

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Matthias MerkerComments to Author , Elena Nikolaevskaya, Thomas A. Kohl, Barbara Molina-Moya, Olha Pavlovska, Patrik Brännberg, Andrii Dudnyk, Valentyna Stokich, Ivan Barilar, Iryna Marynova, Tetiana Filipova, Cristina Prat, Anders Sjöstedt, Jose Dominguez, Olena RzhepishevskaComments to Author , and Stefan Niemann
Author affiliations: Research Center Borstel, Borstel, Germany (M. Merker, T.A. Kohl, I. Barilar, S. Niemann); Odessa Regional TB Hospital, Odessa, Ukraine (E. Nikolaevskaya, O. Pavlovska, V. Stokich); Institut d'Investigació Germans Trias i Pujol, Badalona, Spain (B. Molina-Moya, C. Prat, J. Dominguez); Centro de Investigación Biomédica en Red (CIBERES), Badalona (B. Molina-Moya, C. Prat, J. Dominguez); Universitat Autònoma de Barcelona, Barcelona, Spain (B. Molina-Moya, C. Prat, J. Dominguez); Umeå University, Umea, Sweden (P. Brännberg, A. Sjöstedt, O. Rzhepishevska); National Pirogov Memorial Medical University, Vinnytsia, Ukraine (A. Dudnyk); Odessa I.I. Mechnikov National University, Odessa (I. Marynova, T. Filipova); German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Germany (S. Niemann)

Main Article

Table 2

Percentages of resistance to antimicrobial drugs among Mycobacterium tuberculosis strains identified in southern Ukraine*

Drug All strains, 
n = 177 Ukraine outbreak, n = 18 Europe/Russia W148 outbreak, n = 28 Central Asia outbreak, n = 7 Other Beijing strains, n = 36 Non-Beijing strains, n = 88
Isoniazid 48.0 (54.2) 100 (100) 92.9 (92.9) 100 (100) 27.8 (44.4) 27.3 (33.0)
Rifampin 42.9 (44.3†) 100 (100) 92.9 (92.9) 100 (100) 30.6 (31.4†) 15.9 (18.2)
Streptomycin 45.2 (54.8) 100 (100) 92.9 (92.9) 100 (85.7) 33.33 (47.2) 19.32 (34.1)
Ethambutol 37.3 (36.2) 100 (66.7) 85.7 (75.0) 100 (57.1) 11.11 (38.9) 14.77 (14.8)
Pyrazinamide 31.6 88.9 75 100 13.9 8.0
Ofloxacin 14.7 44.4 35.7 14.3 11.1 3.4
Amikacin 9.6 22.22 21.43 14.3 8.3 3.4
Capreomycin 9.6 22.2 21.4 14.3 8.3 3.4
Kanamycin 19.2 50.0 39.3 14.3 16.7 8.0
Prothionamide 34.5 100 78.6 57.1 11.1 14.8
Cycloserine 0 0 0 0 0 0
Linezolid 1.0 0 0 0 0 1.1
PAS 10.7 0 39.3 0 0 9.1

*Percentages of genotypic (parentheses) and phenotypic (bold text) drug resistance for Mycobacterium tuberculosis complex strains in southern Ukraine. PAS, para-aminosalicylic acid.
†One phenotypic susceptibility test result was not available.

Main Article

Page created: February 20, 2020
Page updated: February 20, 2020
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