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Volume 26, Number 3—March 2020
Research

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore

Yahua Chen, Kalisvar Marimuthu, Jeanette Teo, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Liang De Wang, Sai Rama Sridatta Prakki, Weizhen Xu, Yi Han Tan, Lan Chi Nguyen, Tse Hsien Koh, Oon Tek Ng, and Yunn-Hwen GanComments to Author 
Author affiliations: National University of Singapore, Singapore (Y. Chen, Y.H. Tan, L.C. Nguyen, Y.-H. Gan); National Centre for Infectious Diseases, Singapore (K. Marimuthu, L.D. Wang, S.R.S. Prakki, W. Xu, O.T. Ng); Tan Tock Seng Hospital, Singapore (K. Marimuthu, O.T. Ng); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam, B.P.Z. Cherng, T.H. Koh); Nanyang Technological University, Singapore (O.T. Ng)

Main Article

Figure 6

Timeline showing antimicrobial drug exposure and plasmid changes in 3 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates from patient A2, Singapore, 2013–2014. pMDR646 contains genes aac(6’)-lb-cr,blaOXA-1, qnrB1, catB3, and dfrA14. pMDR1734 contains genes aac(6’)-lb-cr,blaOXA-1, and catB3. pKPC2 contains genes blaKPC-2, blaTEM-1A, blaTEM-1B, and mph(A). KPC, Klebsiella pneumoniae carbapenemase; KPVP, Klebsiella pneumoniae virulence plasmid; MDR, multidrug resistance.

Figure 6. Timeline showing antimicrobial drug exposure and plasmid changes in 3 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates from patient A2, Singapore, 2013–2014. pMDR646 contains genes aac(6’)-lb-cr,blaOXA-1, qnrB1, catB3, and dfrA14. pMDR1734 contains genes aac(6’)-lb-cr, blaOXA-1, and catB3. pKPC2 contains genes blaKPC-2, blaTEM-1A, blaTEM-1B, and mph(A). KPC, Klebsiella pneumoniae carbapenemase; KPVP, Klebsiella pneumoniae virulence plasmid; MDR, multidrug resistance.

Main Article

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Page updated: February 20, 2020
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