Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 26, Number 3—March 2020
Research

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 3

Effect of the Mycobacterium tuberculosis Beijing lineage on the risk for infection at baseline in child and adult household contacts of culture-positive index patients, Lima, Peru, September 2009–August 2012

Lineage
Age <15 y, n = 3,115*

Age >15 y, n = 5,663*
Prevalence, no. (%)†
Risk ratio (95% CI)
Prevalence, no. (%)†
Risk ratio (95% CI)
Univariate
Multivariate‡
Univariate
Multivariate‡
Non-Beijing
731 (26)
Referent
Referent

2,654 (53)
Referent
Referent
Beijing 110 (33) 1.27 (1.06–1.53) 1.23 (1.02–1.50) 353 (53) 0.99 (0.91–1.08) 1.00 (0.91–1.09)

*Likelihood ratio test for the interaction between age (<15 or >15) and index patient M. tuberculosis lineage: p = 0.025.
†Prevalence of baseline M. tuberculosis infection in the univariate model.
‡Multivariate model adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact socioeconomic status; household contact nutritional status.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external