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Volume 26, Number 3—March 2020
Research

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 3

Effect of the Mycobacterium tuberculosis Beijing lineage on the risk for infection at baseline in child and adult household contacts of culture-positive index patients, Lima, Peru, September 2009–August 2012

Lineage
 Age <15 y, n = 3,115*
Age >15 y, n = 5,663*
Prevalence, no. (%)†
 Risk ratio (95% CI)
 Prevalence, no. (%)†
 Risk ratio (95% CI)
Univariate
 Multivariate‡
 Univariate
 Multivariate‡
Non-Beijing
 731 (26)
 Referent
 Referent
2,654 (53)
 Referent
 Referent
Beijing 110 (33) 1.27 (1.06–1.53) 1.23 (1.02–1.50) 353 (53) 0.99 (0.91–1.08) 1.00 (0.91–1.09)

*Likelihood ratio test for the interaction between age (<15 or >15) and index patient M. tuberculosis lineage: p = 0.025.
†Prevalence of baseline M. tuberculosis infection in the univariate model.
‡Multivariate model adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact socioeconomic status; household contact nutritional status.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
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