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Volume 26, Number 3—March 2020
Research

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 4

Effect of the Mycobacterium tuberculosis Beijing lineage on the risk for infection by 12 months of follow-up in child and adult household contacts of culture-positive index patients, Lima, Peru, September 2009–August 2012

Lineage
 Age <15 y, n = 2,521*
Age >15 y, n = 4,921*
Prevalence, no. (%)†
 Risk ratio (95% CI)
 Prevalence, no. (%)†
 Risk ratio (95% CI)
Univariate
 Multivariate‡
 Univariate
 Multivariate‡
Non-Beijing 1,098 (49) Referent Referent 3,546 (82) Referent Referent
Beijing 173 (59) 1.20 (1.08–1.35) 1.22 (1.09–1.38) 474 (82) 1.00 (0.96–1.05) 1.01 (0.97–1.06)

*Likelihood ratio test for the interaction between age (<15 or >15 y) and index patient M. tuberculosis lineage: p = 0.003.
†Prevalence of M. tuberculosis infection by 12 months for the univariate model.
‡Adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact socioeconomic status; household contact nutritional status.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
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