Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 26, Number 3—March 2020
Research

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 6

Hazard ratios of incident tuberculosis among contacts exposed to a Mycobacterium tuberculosis Beijing lineage and a non-Beijing lineage, Lima, Peru, September 2009–August 2012

Lineage
 Age <15 y*
Age >15 y*
Incidence, %†
 Hazard ratio (95% CI)
 Incidence, %†
 Hazard ratio (95% CI)
Univariate
 Multivariate‡
 Univariate
 Multivariate‡
Non-Beijing 3,043 (84/2,760) Referent Referent 2,874 (156/4,993) Referent Referent
Beijing
 4,478 (15/335) 1.42 (0.78–2.59) 1.45 (0.77–2.72) 3,124 (19/661) 0.93 (0.57–1.52) 1.06 (0.64–1.77)

*Likelihood ratio test for the interaction between age (<15 or >15 y) and index patient M. tuberculosis lineage: p = 0.231.
†Per 100,000 person-years in the univariate model.
‡Adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact SES; household contact nutritional status; household contact use of isoniazid preventive therapy; household contact TB history.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external