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Volume 26, Number 3—March 2020
Research

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 6

Hazard ratios of incident tuberculosis among contacts exposed to a Mycobacterium tuberculosis Beijing lineage and a non-Beijing lineage, Lima, Peru, September 2009–August 2012

Lineage
 Age <15 y*
Age >15 y*
Incidence, %†
 Hazard ratio (95% CI)
 Incidence, %†
 Hazard ratio (95% CI)
Univariate
 Multivariate‡
 Univariate
 Multivariate‡
Non-Beijing 3,043 (84/2,760) Referent Referent 2,874 (156/4,993) Referent Referent
Beijing
 4,478 (15/335) 1.42 (0.78–2.59) 1.45 (0.77–2.72) 3,124 (19/661) 0.93 (0.57–1.52) 1.06 (0.64–1.77)

*Likelihood ratio test for the interaction between age (<15 or >15 y) and index patient M. tuberculosis lineage: p = 0.231.
†Per 100,000 person-years in the univariate model.
‡Adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact SES; household contact nutritional status; household contact use of isoniazid preventive therapy; household contact TB history.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
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