Volume 26, Number 4—April 2020
Research
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium
Laura Van Driessche
, Kevin Vanneste, Bert Bogaerts, Sigrid C.J. De Keersmaecker, Nancy H. Roosens, Freddy Haesebrouck, Lieze De Cremer, Piet Deprez, Bart Pardon, and Filip Boyen
, Kevin Vanneste, Bert Bogaerts, Sigrid C.J. De Keersmaecker, Nancy H. Roosens, Freddy Haesebrouck, Lieze De Cremer, Piet Deprez, Bart Pardon, and Filip Boyen
Table 2
Overview of phenotypic and genotypic resistance determinants of all investigated bovine Gallibacterium anatis isolates, Belgium, 2017–2018*
| Isolate | Antimicrobial classes with phenotypic resistance | Identified genotypic resistance determinants |
|---|---|---|
| GB2 |
Macrolides, potentiated sulphonamides, tetracyclines, phenicols, aminoglycosides, fluoroquinolones |
ermB, sul2, tetM, catA1, catA3, floR, aadA1, aadB, aphA1, strA, strB, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB3 |
Penicillins, macrolides, tetracyclines, phenicols, aminoglycosides, fluoroquinolones |
blaCARB-8, blaTEM-2, ermB, sul1, sul2, tetB, tetM, tetY, floR, aadA1, aadB, aphA1, strA, strB, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB4 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, phenicols, aminoglycosides, fluoroquinolones |
blaTEM-2, ermB, dfrA1, sul2, tetB, tetM,catA1, aac(6”)-aph(2”)-1, aadA1, aph(3′)-III, strA, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB5 |
Macrolides, potentiated sulphonamides, tetracyclines, aminoglycosides, fluoroquinolones |
ermB, dfrA1, sul2, tetB, tetM, catA1, floR, aadA1, aadB, aphA1, strA, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB6 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, phenicols, aminoglycosides, fluoroquinolones |
blaCARB-8, blaTEM-2, ermB, dfrA1, sul1, sul2, tetB, tetM, tetY, floR, aadA1, aphA1, strA, strB, gyrA 83S→F, gyrA 87D→G, parC 80S→I |
| GB7 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, aminoglycosides, fluoroquinolones |
blaTEM-2, ermB, sul2, tetB, tetM, catA1, catA3, aadA1, aadB, aphA1, strA, strB, gyrA 83S→F, gyrA 87D→G, parC 80S→I |
| GB8 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, aminoglycosides, fluoroquinolones |
blaTEM-2, ermB, mphE, mrsE, dfrA1, sul2, tetB, tetM, catA1, catA3, aadA23, aadB,aphA1, strA, gyrA 83S→F, gyrA 87D→A, parC 80S→I |
| GB9 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, aminoglycosides, fluoroquinolones |
blaTEM-2, ermB, dfrA1, sul2, tetB, tetM, catA1, aac(6′)-aph(2”)-1, aadA1, aph(3′)-III, strA, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB10 |
Penicillins, macrolides, potentiated sulphonamides, tetracyclines, phenicols, aminoglycosides, fluoroquinolones |
ermB, sul2, tetB, tetM, catA1, floR, aadA1, aadB, aphA1, strA, qnrD1, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
| GB11 | Penicillins, macrolides, potentiated sulphonamides, tetracyclines, aminoglycosides, fluoroquinolones | blaTEM-2, ermB, dfrA1, sul2, tetB, tetM, catA1, aac(6′)-aph(2”), aadA1, aph(3′)-III, strA, gyrA 83S→Y, gyrA 87D→A, parC 80S→I |
*Current Clinical and Laboratory Standards Institute breakpoints for G. anatis were used to define susceptibility. Identified resistance genes are listed with their name as present in the ResFinder database. For gyrA and parC, the resulting amino acid changes at positions 83 and 87 (gyrA) and 80 (parC) are also indicated.
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