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Volume 26, Number 5—May 2020
Research

Possible Transmission Mechanisms of Mixed Mycobacterium tuberculosis Infection in High HIV Prevalence Country, Botswana

Yeonsoo Baik1, Chawangwa Modongo, Patrick K. Moonan, Eleanor S. Click, James L. Tobias, Rosanna Boyd, Alyssa Finlay, John E. Oeltmann, Sanghyuk S. Shin2Comments to Author , and Nicola M. Zetola2
Author affiliations: University of California, Los Angeles, Los Angeles, California, USA (Y. Baik); Botswana–Upenn Partnership, Gaborone, Botswana (C. Modongo, N.M. Zetola); US Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.K. Moonan, E.S. Click, J.L. Tobias, R. Boyd, A. Finlay, J.E. Oeltmann); US Centers for Disease Control and Prevention, Gaborone (R. Boyd, A. Finlay); University of California, Irvine, Irvine, California, USA (S.S Shin)

Main Article

Figure 1

Mixed-strain infection MIRU-VNTR permutations and genotype cluster/noncluster examples of Mycobacterium tuberculosis (the Kopanyo Study), Botswana, 2012–2016. On the basis of mixed-strain MIRU-VNTR patterns, all possible permutations at each of multiple allele loci were considered. The MIRU-VNTR result of each strain in a possible permutation set was compared with that of all strains identified in the study. Assuming numbers of tandem repeats at other 19 loci are identical, 4 genomes (strains A–

Figure 1. Mixed-strain infection MIRU-VNTR permutations and genotype cluster/noncluster examples of Mycobacterium tuberculosis (the Kopanyo Study), Botswana, 2012–2016. On the basis of mixed-strain MIRU-VNTR patterns, all possible permutations at each of multiple allele loci were considered. The MIRU-VNTR result of each strain in a possible permutation set was compared with that of all strains identified in the study. Assuming numbers of tandem repeats at other 19 loci are identical, 4 genomes (strains A–D) in the genotype cluster example (bottom left) have matched tandem repeats at the presented 5 loci of tandem repeats in the mixed-strain infection. Strains E and F in the genotype noncluster example have nonmatched tandem repeats at the second and third locus, respectively. MIRU-VNTR, mycobacterial interspersed repetitive unit–variable-number tandem-repeat.

Main Article

1Current affiliation: Johns Hopkins University, Baltimore, Maryland, USA.

2These senior authors contributed equally to this article.

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Page updated: April 16, 2020
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