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Volume 26, Number 6—June 2020
Dispatch

No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease

Aileen Boyle, Chris Plinston, Fraser Laing, Graeme Mackenzie, Robert G. Will, Jean C. Manson, and Abigail B. DiackComments to Author 
Author affiliations: The Roslin Institute, Easter Bush, Scotland, UK (A. Boyle, C. Plinston, F. Laing, A.B. Diack); Western General Hospital, Edinburgh, Scotland, UK (G. Mackenzie); University of Edinburgh, Edinburgh (R.G. Will, J.C. Manson)

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Figure 1

Vacuolation profiles of a clinical case of vCJD in a prion protein gene codon 129MV individual, pooled data from UK 129MM cases (n = 7) and pooled data from UK bovine spongiform encephalopathy cases (n = 8) show similarities in vacuolar pathology intensity and distribution in wild-type mouse brains. Data show mean ± SEM of clinical and pathological positive mice (n≥6 per group). G1–G9, gray matter scoring regions: G1, medulla; G2, cerebellum; G3, superior colliculus; G4, hypothalamus; G5, thalam

Figure 1. Vacuolation profiles of a clinical case of vCJD in a prion protein gene codon 129MV individual, pooled data from UK 129MM cases (n = 7) and pooled data from UK bovine spongiform encephalopathy cases (n = 8) show similarities in vacuolar pathology intensity and distribution in wild-type mouse brains. Data show mean ± SEM of clinical and pathological positive mice (n≥6 per group). G1–G9, gray matter scoring regions: G1, medulla; G2, cerebellum; G3, superior colliculus; G4, hypothalamus; G5, thalamus; G6, hippocampus; G7, septum; G8, retrosplenial and adjacent motor cortex; G9, cingulate and adjacent motor cortex. W1–W3, white matter scoring regions: W1, cerebellar white matter; W2, mesencephalic tegmentum; W3, cerebral peduncle. MM, methionine homozygous; MV, methionine/valine; vCJD, variant Creutzfeldt-Jakob disease.

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Page created: May 19, 2020
Page updated: May 19, 2020
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