Figure 1. Vacuolation profiles of a clinical case of vCJD in a prion protein gene codon 129MV individual, pooled data from UK 129MM cases (n = 7) and pooled data from UK bovine spongiform encephalopathy cases (n = 8) show similarities in vacuolar pathology intensity and distribution in wild-type mouse brains. Data show mean ± SEM of clinical and pathological positive mice (n≥6 per group). G1–G9, gray matter scoring regions: G1, medulla; G2, cerebellum; G3, superior colliculus; G4, hypothalamus; G5, thalamus; G6, hippocampus; G7, septum; G8, retrosplenial and adjacent motor cortex; G9, cingulate and adjacent motor cortex. W1–W3, white matter scoring regions: W1, cerebellar white matter; W2, mesencephalic tegmentum; W3, cerebral peduncle. MM, methionine homozygous; MV, methionine/valine; vCJD, variant Creutzfeldt-Jakob disease.