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Volume 26, Number 7—July 2020

Dispatch

Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France

Racha BeyrouthyComments to Author , Guillaume Dalmasso, Aurélien Birer, Frédéric Robin, and Richard Bonnet
Author affiliations: Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand, France (R. Beyrouthy, G. Dalmasso, F. Robin, R. Bonnet); Centre National de Référence de la Résistance aux Antibiotiques, Clermont-Ferrand (R. Beyrouthy, A. Birer, F. Robin, R. Bonnet); Centre Hospitalier Universitaire, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Institut National de la Recherche Agronomique (USC-2018), Clermont-Ferrand (R. Beyrouthy, F. Robin, G. Dalmasso, R. Bonnet) ; Université Clermont Auvergne, Clermont-Ferrand (G. Dalmasso, F. Robin, R. Bonnet)

Main Article

Table

Characteristics of carbapenem and hypervirulent Klebsiella pneumoniae isolates from 2 patients, France, 2017*

Characteristic Kpn154 strain Kpn2166 strain
Patient age, y/sex 35/M 70/M
Sample, context
 Urine, community-acquired UTI
 Feces, hospital-acquired intestinal carriage
MIC, μg/mL
Ertapenem 2 32
Imipenem
 10
 10
Meropenem 2 4
Ceftazidime
 0.125
 >256
Ceftriaxone 0.5 >256
Cefotaxime
 0.5
 >256
Cefepime 0.25 >256
Aztreonam
 0.06
 >256
Temocillin 256 32
Tigecyclin
 1
 4
Colistin
 0.5
 0.5
Genome size, sequencing depth 5,555,907 bp, 120× 5,649,836 bp, 145×
Genotype K2-ST86 K2-ST86
Resistance replicon, bp
 IncL, 100,326
 IncN, 61,761
Resistance marker blaOXA-48 blaCTX-M-15, ΔompK36, ΔramR
Virulence replicon
 IncHI1B/IncFIB, 215,306
 IncHI1B/IncFIB, 226,677
Capsule regulator rmpA.2, rmpA2† rmpA.2, ΔrmpA2‡
Aerobactin-ST§
 AbST1: iucA1B1C1D1iutA1
 AbST1: iucA1B1C1D1iutA1
Salmochelin-ST§ SmST1: iroB1C1D1N1 SmST1: iroB1C1D1N1
Yersiniabactin-ST§ ICEKp3-YbST202LV ICEKp12like- YbST13LV

*K, capsular genotype; ST, sequence type; UTI, urinary tract infection.
†New rmpA2 allele.
‡Truncated allele harboring a frameshift mutation at base 222.
§Genotyped based on Kleborate schemes.

Main Article

Page created: April 10, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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