Volume 26, Number 7—July 2020
Dispatch
Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France
Table
Characteristics of carbapenem and hypervirulent Klebsiella pneumoniae isolates from 2 patients, France, 2017*
Characteristic | Kpn154 strain | Kpn2166 strain |
---|---|---|
Patient age, y/sex | 35/M | 70/M |
Sample, context |
Urine, community-acquired UTI |
Feces, hospital-acquired intestinal carriage |
MIC, μg/mL | ||
Ertapenem | 2 | 32 |
Imipenem |
10 |
10 |
Meropenem | 2 | 4 |
Ceftazidime |
0.125 |
>256 |
Ceftriaxone | 0.5 | >256 |
Cefotaxime |
0.5 |
>256 |
Cefepime | 0.25 | >256 |
Aztreonam |
0.06 |
>256 |
Temocillin | 256 | 32 |
Tigecyclin |
1 |
4 |
Colistin |
0.5 |
0.5 |
Genome size, sequencing depth | 5,555,907 bp, 120× | 5,649,836 bp, 145× |
Genotype | K2-ST86 | K2-ST86 |
Resistance replicon, bp |
IncL, 100,326 |
IncN, 61,761 |
Resistance marker | blaOXA-48 | blaCTX-M-15, ΔompK36, ΔramR |
Virulence replicon |
IncHI1B/IncFIB, 215,306 |
IncHI1B/IncFIB, 226,677 |
Capsule regulator | rmpA.2, rmpA2† | rmpA.2, ΔrmpA2‡ |
Aerobactin-ST§ |
AbST1: iucA1B1C1D1iutA1 |
AbST1: iucA1B1C1D1iutA1 |
Salmochelin-ST§ | SmST1: iroB1C1D1N1 | SmST1: iroB1C1D1N1 |
Yersiniabactin-ST§ | ICEKp3-YbST202LV | ICEKp12like- YbST13LV |
*K, capsular genotype; ST, sequence type; UTI, urinary tract infection.
†New rmpA2 allele.
‡Truncated allele harboring a frameshift mutation at base 222.
§Genotyped based on Kleborate schemes.