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Volume 26, Number 7—July 2020
Dispatch

Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France

Racha BeyrouthyComments to Author , Guillaume Dalmasso, Aurélien Birer, Frédéric Robin, and Richard Bonnet
Author affiliations: Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand, France (R. Beyrouthy, G. Dalmasso, F. Robin, R. Bonnet); Centre National de Référence de la Résistance aux Antibiotiques, Clermont-Ferrand (R. Beyrouthy, A. Birer, F. Robin, R. Bonnet); Centre Hospitalier Universitaire, Clermont-Ferrand (R. Beyrouthy, F. Robin, R. Bonnet); Institut National de la Recherche Agronomique (USC-2018), Clermont-Ferrand (R. Beyrouthy, F. Robin, G. Dalmasso, R. Bonnet) ; Université Clermont Auvergne, Clermont-Ferrand (G. Dalmasso, F. Robin, R. Bonnet)

Main Article

Table

Characteristics of carbapenem and hypervirulent Klebsiella pneumoniae isolates from 2 patients, France, 2017*

Characteristic Kpn154 strain Kpn2166 strain
Patient age, y/sex 35/M 70/M
Sample, context
 Urine, community-acquired UTI
 Feces, hospital-acquired intestinal carriage
MIC, μg/mL
Ertapenem 2 32
Imipenem
 10
 10
Meropenem 2 4
Ceftazidime
 0.125
 >256
Ceftriaxone 0.5 >256
Cefotaxime
 0.5
 >256
Cefepime 0.25 >256
Aztreonam
 0.06
 >256
Temocillin 256 32
Tigecyclin
 1
 4
Colistin
 0.5
 0.5
Genome size, sequencing depth 5,555,907 bp, 120× 5,649,836 bp, 145×
Genotype K2-ST86 K2-ST86
Resistance replicon, bp
 IncL, 100,326
 IncN, 61,761
Resistance marker blaOXA-48 blaCTX-M-15, ΔompK36, ΔramR
Virulence replicon
 IncHI1B/IncFIB, 215,306
 IncHI1B/IncFIB, 226,677
Capsule regulator rmpA.2, rmpA2† rmpA.2, ΔrmpA2‡
Aerobactin-ST§
 AbST1: iucA1B1C1D1iutA1
 AbST1: iucA1B1C1D1iutA1
Salmochelin-ST§ SmST1: iroB1C1D1N1 SmST1: iroB1C1D1N1
Yersiniabactin-ST§ ICEKp3-YbST202LV ICEKp12like- YbST13LV

*K, capsular genotype; ST, sequence type; UTI, urinary tract infection.
†New rmpA2 allele.
‡Truncated allele harboring a frameshift mutation at base 222.
§Genotyped based on Kleborate schemes.

Main Article

Page created: April 10, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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