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Volume 26, Number 7—July 2020
Dispatch

Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2

Susanna K.P. Lau1Comments to Author , Hayes K.H. Luk1, Antonio C.P. Wong1, Kenneth S.M. Li, Longchao Zhu, Zirong He, Joshua Fung, Tony T.Y. Chan, Kitty S.C. Fung, and Patrick C.Y. WooComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (S.K.P. Lau, H.K.H. Luk, A.C.P. Wong, K.S.M. Li, L. Zhu, Z. He, J. Fung, T.T.Y. Chan, P.C.Y. Woo); United Christian Hospital, Hong Kong (K.S.C. Fung)

Main Article

Figure 2

Bootscan analysis and nucleotide sequence alignment for SARS-CoV-2 isolates and closely related viruses. A) Boot scan analysis using the partial spike gene (positions 22397–23167) of SARS-CoV-2 strain HK20 as query sequence. Bootscanning was conducted with Simplot version 3.5.1 (https://sray.med.som) (F84 model; window size, 100 bp; step, 10 bp) on nucleotide alignment, generated with ClustalX (http://www.clustal.org). B) Multiple alignment of nucleotide sequences from genome positions 22300 to

Figure 2. Bootscan analysis and nucleotide sequence alignment for SARS-CoV-2 isolates and closely related viruses. A) Boot scan analysis using the partial spike gene (positions 22397–23167) of SARS-CoV-2 strain HK20 as query sequence. Bootscanning was conducted with Simplot version 3.5.1 (https://sray.med.som) (F84 model; window size, 100 bp; step, 10 bp) on nucleotide alignment, generated with ClustalX (http://www.clustal.org). B) Multiple alignment of nucleotide sequences from genome positions 22300 to 23700. Yellow indicates receptor binding domain; orange indicates receptor binding motif; pink indicates bases conserved between SARS-CoV-2 HK20 and Pangolin-SARSr-CoV/MP789/Guangdong/2019; and blue indicates bases conserved between SARS-CoV-2 HK20 and SARSr-Ra-BatCoVs RaTG13.

Main Article

1These authors contributed equally to this article.

Page created: April 21, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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