Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020
Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas Dauby
, Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther
1, and Michèle Gérard
1
Author affiliations: Université de Bruxelles, Brussels, Belgium (I. Veliziotis, A. Roman, D. Martiny, M. Claus, N. Dauby, S. Van den Wijngaert, C. Martin, R. Nasreddine, D. Konopnicki, E. Stevens, P. Dechamps, O. Vandenberg, M. Gérard); Saint-Pierre University Hospital, Brussels (I. Veliziotis, A, Roman, M. Claus, N. Dauby, C. Martin, R. Nasreddine, S. Van Praet, D. Konopnicki, E. Stevens, P. Deschamps, M. Gérard); Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. (G. Schuldt, S. Günther); National Administration of Laboratories and Institutes of Health, Buenos Aires, Argentina (C. Perandones); Common Community Commission, Brussels (R. Mahieu); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (C. Swaan); Instituto Nacional de Enfermedades Virales Humanas, Pergamino, Argentina (M.A. Morales); World Health Organization Collaborating Centre for Reference and Research of Arbovirus and Hemorrhagic Fever Virosis, Pergamino (M.A. Morales); University Hospital Center of Bordeaux, Bordeaux, France (D. Malvy); University Hospital Antwerp, Belgium (E. Vlieghe); University College London, London, UK (O. Vandenberg)
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Figure
Figure. Biologic and virologic evolution in relation to treatment and supportive care for a patient with Argentine hemorrhagic fever, Belgium, 2020. A) Evolution of maximum daily temperature and blood and urine viral load during hospitalization. Antiviral and antimicrobial drug treatment scheme are shown. Dosages of FVP are indicated in grams. B) Evolution of hemoglobin, total leukocytes, and platelets during hospitalization. Solid arrows indicate administration of red blood cell units, and dashed arrows indicate administration of G-CSF. Ct values <40 indicate undetectable viral load. CRO, ceftriaxone; Ct, cycle threshold; CXM, cefuroxime; FVP, favipiravir; G-CSF, granulocyte colony-stimulating factor; MEM, meropenem; Neg., negative; RBV, ribavirin; TZP, piperacillin/tazobactam; VRC, voriconazole; WBC, white blood cells.
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Page created: April 09, 2020
Page updated: June 18, 2020
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