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Volume 26, Number 8—August 2020

Dispatch

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu DurukanComments to Author , Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric P.F. Chow, Jorgen S. Jensen, Christopher K. Fairley, Ivette Aguirre, and Catriona S. Bradshaw
Author affiliations: Alfred Health, Carlton, Victoria, Australia (D. Durukan, M. Doyle, L. Vodstrcil, E.P.F. Chow, C.K. Fairley, I. Aguirre, C.S. Bradshaw); Monash University, Clayton, Victoria, Australia (D. Durukan, L. Vodstrcil, E.P.F. Chow, C.K. Fairley, C.S. Bradshaw); Royal Children’s Hospital, Parkville, Victoria, Australia (G. Murray, K. Bodiyabadu); The Royal Women’s Hospital, Parkville (G. Murray, K. Bodiyabadu); Statens Serum Institut, Copenhagen, Denmark (J.S. Jensen)

Main Article

Figure

Clinical approach and treatment for patients with diagnosed macrolide-resistant Mycoplasma genitalium at Melbourne Sexual Health Centre, Australia. PID, pelvic inflammatory disease; STI, sexually transmitted infection. *Routine testing with the ResistancePlus MG assay (SpeeDx, https://plexpcr.com). †Moxifloxacin 400 mg/day for 14 days. ‡Doxycycline 100 mg 2 times/day for 7 days, then moxifloxacin 400 mg/d for 7 days. §Test of cure was recommended 14–28 days after completing antimicrobial treatme

Figure. Clinical approach and treatment for patients with diagnosed macrolide-resistant Mycoplasma genitalium at Melbourne Sexual Health Centre, Australia. PID, pelvic inflammatory disease; STI, sexually transmitted infection. *Routine testing with the ResistancePlus MG assay (SpeeDx, https://plexpcr.com). †Moxifloxacin 400 mg/day for 14 days. ‡Doxycycline 100 mg 2 times/day for 7 days, then moxifloxacin 400 mg/d for 7 days. §Test of cure was recommended 14–28 days after completing antimicrobial treatment and all patients received a reminder. ResistancePlus MG Assay was used for all tests of cure. ¶When sequential therapy failed, patients were given a pristinamycin-based regimen for 10 days, either 1 g 4 times/day alone or 1 g 3 times/day in combination with doxycycline 100 mg 2 times/day. Doxycycline pretreatment also was given to some patients. #Doxycycline 100 mg and sitafloxacin 100 mg taken together 2 times/day for 7 days.

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Page created: June 08, 2020
Page updated: July 18, 2020
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