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Volume 26, Number 8—August 2020
Dispatch

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu DurukanComments to Author , Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric P.F. Chow, Jorgen S. Jensen, Christopher K. Fairley, Ivette Aguirre, and Catriona S. Bradshaw
Author affiliations: Alfred Health, Carlton, Victoria, Australia (D. Durukan, M. Doyle, L. Vodstrcil, E.P.F. Chow, C.K. Fairley, I. Aguirre, C.S. Bradshaw); Monash University, Clayton, Victoria, Australia (D. Durukan, L. Vodstrcil, E.P.F. Chow, C.K. Fairley, C.S. Bradshaw); Royal Children’s Hospital, Parkville, Victoria, Australia (G. Murray, K. Bodiyabadu); The Royal Women’s Hospital, Parkville (G. Murray, K. Bodiyabadu); Statens Serum Institut, Copenhagen, Denmark (J.S. Jensen)

Main Article

Table 2

Amino acid changes in the quinolone resistance–determining regions of parC and gyrA genes of macrolide-resistant Mycoplasma genitalium in patients treated with combination therapy, Melbourne Sexual Health Centre, Carlton, Victoria, Australia*

Case no. Sexual orientation Baseline test
 TOC after first-line therapy
 TOC after second-line therapy
 TOC after third-line therapy
parC gyrA parC gyrA parC gyrA parC gyrA
1 MSM NA NA S83I n/A S83I D99N Cured
2 MSM S83I M95I S83I M95I S83I M95I Cured
3 MSM S83I WT S83I WT S83I WT Cured
4 MSW NA NA NA NA S83I A79S Cured
5 MSW D87N WT D87N WT D87N WT Cured
6 MSW NA NA S83I WT S83I WT Cured
7 MSW S83I WT S83I WT S83I WT Cured
8 MSM S83I WT S83I WT S83I WT Cured
9 MSW S83I WT S83I WT S83I WT S83I WT
10 MSM NA NA S83I WT S83I WT Cured
11 W S83I WT S83I M95I ND ND Cured
12 W S83I M95I S83I M95I S83I M95I Cured

*MSM, men who have sex with men; MSW, men who have sex with women only; NA, sample was not available for sequencing; ND, not done; W, heterosexual woman; WT, wild type.

Main Article

Page created: June 08, 2020
Page updated: July 18, 2020
Page reviewed: July 18, 2020
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