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Volume 26, Number 9—September 2020
Synopsis

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

Roosecelis B. Martines1Comments to Author , Jana M. Ritter1, Eduard Matkovic, Joy Gary, Brigid C. Bollweg, Hannah Bullock, Cynthia S. Goldsmith, Luciana Silva-Flannery, Josilene N. Seixas, Sarah Reagan-Steiner, Timothy Uyeki, Amy Denison, Julu Bhatnagar, Wun-Ju Shieh, Sherif R. Zaki, and COVID-19 Pathology Working Group
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.B. Martines, J.M. Ritter, E. Matkovic, J. Gary, B.C. Bollweg, C.S. Goldsmith, L. Silva-Flannery, J.N. Seixas, S. Reagan-Steiner, T. Uyeki, A. Denison, J. Bhatnagar, W.-J. Shieh, S.R. Zaki); Synergy America Inc., Atlanta (H. Bullock).

Main Article

Figure 3

Immunostaining of severe acute respiratory syndrome coronavirus 2 in pulmonary tissues from fatal coronavirus disease cases. A) Patient no. 5: scattered immunostaining of tracheal epithelial cells (original magnification ×40). B) Patient no. 5: higher magnification shows immunostaining of ciliated cells (original magnification ×63). C) Patient no. 8: immunostaining of desquamated type I pneumocyte in an alveolar lumen (original magnification ×63). D) Patient no. 4: colocalization of SARS-CoV-2 v

Figure 3. Immunostaining of severe acute respiratory syndrome coronavirus 2 in pulmonary tissues from fatal coronavirus disease cases. A) Patient no. 5: scattered immunostaining of tracheal epithelial cells (original magnification ×40). B) Patient no. 5: higher magnification shows immunostaining of ciliated cells (original magnification ×63). C) Patient no. 8: immunostaining of desquamated type I pneumocyte in an alveolar lumen (original magnification ×63). D) Patient no. 4: colocalization of SARS-CoV-2 viral antigen (red) with type II pneumocyte stained by surfactant (brown; arrow) (original magnification ×63). E) Patient no. 4: colocalization of SARS-CoV-2 viral antigen (red) with macrophages stained by CD163 (brown; arrows); virus immunostaining within type II pneumocytes is also seen (arrowheads) (original magnification ×40). F) Patient no. 4: extensive immunostaining of hyaline membranes in a region of exudative DAD (original magnification ×20). G) Patient no. 3: scattered immunostaining within macrophage in hilar lymph node; anthracosis is also present (original magnification ×63).

Main Article

1These authors contributed equally to this article.

2Members of the COVID-19 Pathology Working Group: Rhonda Cole, Amanda Lewis, Pamela Fair, Lindsey Estetter.

Page created: May 21, 2020
Page updated: August 18, 2020
Page reviewed: August 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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