Volume 26, Number 9—September 2020
Synopsis
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020
Karima Benameur1
, Ankita Agarwal1, Sara C. Auld, Matthew P. Butters, Andrew S. Webster, Tugba Ozturk, J. Christina Howell, Leda C. Bassit, Alvaro Velasquez, Raymond F. Schinazi, Mark E. Mullins, and William T. Hu
, Ankita Agarwal1, Sara C. Auld, Matthew P. Butters, Andrew S. Webster, Tugba Ozturk, J. Christina Howell, Leda C. Bassit, Alvaro Velasquez, Raymond F. Schinazi, Mark E. Mullins, and William T. Hu
Table
Characteristics of 3 patients with coronavirus disease and neurologic complications, Atlanta, Georgia, USA, 2020*
| Characteristic | Patient 1 | Patient 2 | Patient 3 |
|---|---|---|---|
| Neurologic findings | |||
| Encephalopathy | Coma | Moderate | Mild |
| Brainstem reflexes affected | All | Corneal gag | Oculocephalic |
| Myoclonus | None | Arms | All limbs |
| Withdrawal to pain |
Absent |
Absent |
Absent |
| CSF findings, reference value | |||
| Appearance, clear | Cloudy | Clear | Clear |
| Opening pressure, 10–20 cm H2O |
30 |
48 |
12 |
| Nucleated cells | |||
| Total, 0–5/μL | 115 | 1 | 0 |
| % Neutrophils, 0%–6% | 51 | 75 | 0 |
| % Lymphocytes, 40%–80% | 10 | 25 | 0 |
| % Macrophages 15%–45% |
39 |
0 |
0 |
| Erythrocytes, 0/μL | 3,426 | 29 | 7 |
| Glucose, 40–70, mg/dL | 40 | 111 | 88 |
| Protein, 15–45, mg/dL | >200 | 37 | 21 |
*CSF, cerebrospinal fluid.
1These authors contributed equally to this article.
Page created: May 27, 2020
Page updated: August 18, 2020
Page reviewed: August 18, 2020
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