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Volume 26, Number 9—September 2020
Research Letter

Asymptomatic SARS-CoV-2 Infection in Nursing Homes, Barcelona, Spain, April 2020

Blanca Borras-Bermejo1, Xavier Martínez-Gómez1, María Gutierrez San Miguel, Juliana Esperalba, Andrés Antón, Elisabet Martin, Marta Selvi, María José Abadías, Antonio Román, Tomàs Pumarola, Magda CampinsComments to Author , and Benito Almirante
Author affiliations: Vall d’Hebron Hospital Universitari, Barcelona, Spain (B. Borras-Bermejo, X. Martínez-Gómez, M. Gutierrez-San Miguel, J. Esperalba, A. Antón, M.J. Abadías, A. Román, T. Pumarola, M. Campins, B. Almirante); Universitat Autònoma de Barcelona, Bellaterra, Spain (X. Martínez-Gómez, A. Antón, A. Román, T. Pumarola, M. Campins, B. Almirante); Servei Atenció Primària Muntanya, Barcelona (E. Martin); Centre d’Atenció Primària Sant Andreu, Barcelona (M. Selvi)

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Abstract

During the coronavirus disease pandemic in Spain, from April 10–24, 2020, a total of 5,869 persons were screened for severe acute respiratory syndrome coronavirus 2 at nursing homes. Among residents, 768 (23.9%) tested positive; among staff, 403 (15.2%). Of those testing positive, 69.7% of residents and 55.8% of staff were asymptomatic.

As of April 2020, Spain was one of the countries accounting for the most coronavirus disease (COVID-19) deaths (1). More than half of those deaths occur in persons >80 years of age (2), which highlights the vulnerability of the elderly. Moreover, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be easily spread within nursing homes, causing outbreaks with high associated mortality rate (3,4). By the beginning of April, the exponential increase of cases overwhelmed the healthcare system in Spain. In this context, rapid outbreak identification and early intervention in nursing homes was needed.

At Vall d’Hebron Hospital, a tertiary hospital in Catalonia, Spain, we conducted test-based screening as a containment measure to promptly implement effective prevention and control measures in nursing homes. We present the early results of a coordinated intervention with primary care teams in ≈6,000 residents and facility staff in nursing homes in our catchment area.

We evaluated 69 nursing homes that had a total census of 6,714 persons. We excluded previous laboratory-confirmed cases of COVID-19. During April 10–24, an integrated team of hospital and primary care staff obtained samples for SARS-CoV-2 testing from all residents and workers: nasopharyngeal and oropharyngeal swab samples both combined in the same collection tube with viral transport media. We used a commercial CE-IVD–marked, real-time reverse transcription PCR–based assay (Cobas SARS-CoV-2; Roche Diagnostics, https://www.roche.com) on a Cobas 6800 system.

Each nursing home director recorded any symptoms present at least 48 hours before the scheduled day of testing for all residents and staff. According to the World Health Organization case definition of a suspected case of COVID-19, a person was classified as symptomatic if fever or acute respiratory symptoms were present at any moment during the preceding 14 days. In the absence of either, the person was considered to be asymptomatic.

We obtained a total of 5,869 samples, 3,214 from residents and 2,655 from facility staff. Overall, 768 (23.9%) residents and 403 (15.2%) staff members tested positive for SARS-CoV-2 (Table). The presence of fever or respiratory symptoms during the preceding 14 days was recorded in 2,624 residents (81.6%) and 1,772 staff members (66.7%). Among those testing positive and for whom we had information about symptoms, 69.7% of the residents and 55.8% of staff were asymptomatic.

On the basis of laboratory results, we planned specific infection prevention and control measures, adapted to facility characteristics in <72 hours. The most relevant measures applied included isolation of infected residents, establishing cohorted areas and designated staff, excluding infected staff from work, ensuring proper supply of personal protection equipment, and training staff about contact- and droplet-based precautions. We established coordinated follow-up evaluation with primary care teams and facility directors.

COVID-19 heavily affected nursing homes, causing uncountable deaths in Spain (5,6). Restriction policies for visitors in nursing homes were described as part of the state of emergency declared on March 14 (7), but a national guideline to reduce the risk for SARS-CoV-2 transmission in these settings was not available until March 24 (8). Moreover, despite knowledge of community transmission starting in late February, widespread testing for SARS-CoV-2 was not available until mid-April.

Our data show an overall high prevalence of SARS-CoV-2 infection in residents and staff, noting a high transmission in these settings. Specific aspects of nursing homes (shared rooms or bathrooms, physically or cognitively impaired residents requiring high-demand care, rotating staff working in different facilities) and a limited adoption of prevention and control measures as reported by our teams are some factors that may explain these results. Among those with known symptom status, we found a high proportion of asymptomatic cases: 69.7% of infected residents and 55.8% of infected staff.

Our study had several limitations. The ascertainment process could lead to misclassification due to atypical symptoms in the elderly. Furthermore, cross-sectional symptom assessment and testing did not allow us to differentiate between presymptomatic and asymptomatic cases. Nevertheless, these values are consistent with a study performed in a nursing facility in King County, Washington, USA, in which 56% of the residents testing positive were asymptomatic (9).

Given that presymptomatic and asymptomatic transmission has been demonstrated (10), our data suggest that asymptomatic cases could have had an important role in transmission dynamics. Symptoms-based approaches would have failed to correctly identify cases and therefore continued transmission. Furthermore, testing of facility staff should be included as part of the prevention and control measures, because they may contribute to sustained transmission.

In conclusion, the high prevalence of SARS-CoV-2 cases found in nursing homes highlights that this vulnerable population requires special attention and proactive interventions in coordination with the primary care teams. In the context of established community transmission of SARS-CoV-2, we recommend implementing test-based screening irrespective of symptomatology in nursing homes as the best approach to rapidly implement prevention and control measures.

Dr. Borras-Bermejo is a preventive medicine and public health physician working in the Preventive Medicine and Epidemiology Department in Vall d’Hebron University Hospital, Barcelona, Spain. Her research interests include vaccines and hospital infection prevention and control.

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Acknowledgment

We thank the Preventive Medicine and Epidemiology Department, Microbiology Department, and primary care teams, along with nursing home directors and staff, who actively collaborated in the implementation in a tight timeframe. We thank Friedel Laaf for the language review.

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References

  1. World Health Organization. Coronavirus disease (COVID-19) situation report 106. 2020 [cited 2020 June 4]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports
  2. Centro de Coordinación de Alertas y Emergencias Sanitarias. Dirección General de Salud Pública, Calidad e Innovación. Update 108. Coronavirus disease (COVID-19) [in Spanish]. 2020 May 17 [cited 2020 May 21].
  3. Comas-Herrera  A, Zalakain  J. Mortality associated with COVID-19 outbreaks in care homes: early international evidence. 2020 [cited 2020 May 21]. https://ltccovid.org/2020/04/12/mortality-associated-with-covid-19-outbreaks-in-care-homes-early-international-evidence
  4. Etard  J-F, Vanhems  P, Atlani-Duault  L, Ecochard  R. Potential lethal outbreak of coronavirus disease (COVID-19) among the elderly in retirement homes and long-term facilities, France, March 2020. Euro Surveill. 2020;25:810. DOIPubMed
  5. Rada  AG. Covid-19: the precarious position of Spain’s nursing homes. BMJ. 2020;369:m1554. DOIPubMed
  6. Danis  K, Fonteneau  L, Georges  S, Daniau  C, Bernard-Stoecklin  S, Domegan  L, et al.; ECDC Public Health Emergency Team. High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020. Euro Surveill. 2020;25:15.PubMed
  7. Ministerio de la Presidencia relaciones con las cortes y memoria democrática. Royal Decree 463/2020 (March 14) declaring the alarm state for the health crisis management situation caused by COVID-19. BOE no 67 from March 14, 2020 [in Spanish]. 2020 Mar 14;67(I):25390–400 [cited 2020 May 21]. https://www.boe.es/diario_boe/txt.php?id=BOE-A-2020-3692
  8. Ministerio de Sanidad. Guideline for the prevention and control of COVID-19 in nursing homes and other residential social services [in Spanish]. 2020 [cited 2020 May 21]. https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Residencias_y_centros_sociosanitarios_COVID-19.pdf
  9. Arons  MM, Hatfield  KM, Reddy  SC, Kimball  A, James  A, Jacobs  JR, et al.; Public Health–Seattle and King County and CDC COVID-19 Investigation Team. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. N Engl J Med. 2020;382:208190. DOIPubMed
  10. He  X, Lau  EHY, Wu  P, Deng  X, Wang  J, Hao  X, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:6725. DOIPubMed

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Table

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Cite This Article

DOI: 10.3201/eid2609.202603

Original Publication Date: June 23, 2020

1These first authors contributed equally to this article.

Table of Contents – Volume 26, Number 9—September 2020

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Magda Campins, Servei de Medicina Preventiva i Epidemiologia, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain

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Page created: June 19, 2020
Page updated: August 20, 2020
Page reviewed: August 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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