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Volume 27, Number 1—January 2021
Research

Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance

Natália C.C. de Azevedo FernandesComments to Author , Juliana M. Guerra, Josué Díaz-Delgado, Mariana S. Cunha, Leila delC. Saad, Silvia D. Iglezias, Rodrigo A. Ressio, Cinthya dos Santos Cirqueira, Cristina T. Kanamura, Isis P. Jesus, Adriana Y. Maeda, Fernanda G.S. Vasami, Júlia de Carvalho, Leonardo J.T. de Araújo, Renato Pereira de Souza, Juliana S. Nogueira, Roberta M.F. Spinola, and José L. Catão-Dias
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, M.S. Cunha, S.D. Iglezias, R.A. Ressio, C. dos Santos Cirqueira, C.T. Kanamura, I.P. Jesus, A.Y. Maeda, F.G.S. Vasami, J. de Carvalho, L.T. de Araújo, R. Pereira de Souza, J.S. Nogueira); Universidade de São Paulo, São Paulo (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, J.L. Catão-Dias); Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA (J. Díaz-Delgado); Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac, São Paulo (L.D.C. Saad, R.M.F. Spinola)

Main Article

Figure 1

Photomicrographs of liver from human patient (A, C) and Callicebus spp. monkey (B, D) with full spectrum of yellow fever (YF)–associated lesions, Brazil. Midzonal necrosis with multiple Councilman-Rocha Lima bodies (arrows), mild steatosis, and hepatocytes with eosinophilic nucleoli (Torres body [Xs]) (hematoxylin and eosin stained). B) Necrosis/apoptosis (diffuse and panlobular), associated with multiple Councilman-Rocha Lima bodies (arrows) and a few remaining viable hepatocytes (arrowheads) in periportal area (hematoxylin and eosin stained). C) Positive, multifocal immunolabeling for YF antigen (arrowheads) (anti-YF, Warp red, counterstained with hematoxylin). D) Intense and diffuse immunolabeling for YF antigen (anti-YF, 3,3'-diaminobenzidine counterstaining with hematoxylin). Scale bars indicate 50 µm.

Figure 1. Photomicrographs of liver from human patient (A, C) and Callicebus spp. monkey (B, D) with full spectrum of yellow fever (YF)–associated lesions, Brazil. Midzonal necrosis with multiple Councilman-Rocha Lima bodies (arrows), mild steatosis, and hepatocytes with eosinophilic nucleoli (Torres body [Xs]) (hematoxylin and eosin stained). B) Necrosis/apoptosis (diffuse and panlobular), associated with multiple Councilman-Rocha Lima bodies (arrows) and a few remaining viable hepatocytes (arrowheads) in periportal area (hematoxylin and eosin stained). C) Positive, multifocal immunolabeling for YF antigen (arrowheads) (anti-YF, Warp red, counterstained with hematoxylin). D) Intense and diffuse immunolabeling for YF antigen (anti-YF, 3,3'-diaminobenzidine counterstaining with hematoxylin). Scale bars indicate 50 µm.

Main Article

Page created: October 05, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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