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Volume 27, Number 1—January 2021
Research

Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance

Natália C.C. de Azevedo FernandesComments to Author , Juliana M. Guerra, Josué Díaz-Delgado, Mariana S. Cunha, Leila delC. Saad, Silvia D. Iglezias, Rodrigo A. Ressio, Cinthya dos Santos Cirqueira, Cristina T. Kanamura, Isis P. Jesus, Adriana Y. Maeda, Fernanda G.S. Vasami, Júlia de Carvalho, Leonardo J.T. de Araújo, Renato Pereira de Souza, Juliana S. Nogueira, Roberta M.F. Spinola, and José L. Catão-Dias
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, M.S. Cunha, S.D. Iglezias, R.A. Ressio, C. dos Santos Cirqueira, C.T. Kanamura, I.P. Jesus, A.Y. Maeda, F.G.S. Vasami, J. de Carvalho, L.T. de Araújo, R. Pereira de Souza, J.S. Nogueira); Universidade de São Paulo, São Paulo (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, J.L. Catão-Dias); Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA (J. Díaz-Delgado); Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac, São Paulo (L.D.C. Saad, R.M.F. Spinola)

Main Article

Table 3

Performance of histopathologic analysis in diagnosing yellow fever in NWPs and humans, Brazil*

Category Sensitivity Specificity PPV NPV IHC and qRT-PCR agreement, κ
NWPs
All genera 94.1 (91.6–96.1) 99.5 (98.8–99.8) 98.6 (97–99.4) 97.6 (96.6–98.3) 0.97 (0.91–0.96)
Alouatta 97.3 (95.3–98.7) 98.2 (95.6–99.5) 99 (97–99.4) 95.3 (91.9–97.3) 0.95 (0.92–0.98)
Callithrix 37.5 (18.8–59.4) 99.9 (99.3–100.0) 90.0 (54.3–98.6) 98.2 (97.5–98.7) 0.47 (0.25–0.70)
Sapajus 100 (73.5–100.0) 100 (94.4–100.0) 100 (94.4–100.0) 100.0 (94.4–100.0) 0.90 (0.70–1.00)
Callicebus
 88.9 (51.7–99.7)
 94.7 (74.0–99.9)
 88.9 (53.9–98.2)
 94.7 (73.9–99.1)
 0.85 (0.56–1.00)
Humans 97.9 (88.7–99.9) 97.8 (88.5–99.9) 97.9 (86.9–99.7) 97.8 (86.6–99.7) 0.96 (0.90–1.00)

*Values are % (95% CI). IHC, immunohistochemical analysis; NPV, negative predictive value; NWPs, New Word primates; PPV, positive predictive value; RT-qPCR, reverse transcription quantitative PCR.

Main Article

Page created: October 05, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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