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Volume 27, Number 10—October 2021

Fatal Cowpox Virus Infection in Human Fetus, France, 2017

Audrey Ferrier1, Gaelle Frenois-Veyrat1, Evelyne Schvoerer, Sandrine Henard, Fanny Jarjaval, Isabelle Drouet, Hawa Timera, Laetitia Boutin, Estelle Mosca, Christophe Peyrefitte, and Olivier FerrarisComments to Author 
Author affiliations: Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France (A. Ferrier, G. Frenois-Veyrat, F. Jarjaval, I. Drouet, H. Timera, L. Boutin, E. Mosca, C. Peyrefitte, O. Ferraris); Centre Hospitalier Régional Universitaire, Nancy, France (E. Schvoerer, S. Henard)

Main Article


Quantification of genomic or infectious CPXV in samples and CPXV-specific IgG detection in serum of mother and fetus, France, 2017*

Samples Jul 19, 29 dpi
Jul 21, 31 dpi
Aug 3, 44 dpi
Aug 30, 71 dpi
Cutaneous biopsy Plasma Cutaneous biopsy Fetus Placenta Vaginal swab Plasma Vaginal swab Plasma
DNA, copies/μL 2.4×104 26.6 8.6 × 106 1.6 × 106 1.4 × 106 2.0 × 104 27
Infectious virus, TCID50/mL NT 1.86 × 107 2.32 × 107 9.74 × 107 1.95 × 108
CPXV-specific IgG NA ++ NA NA NA NA ++ NA +++

*CPXV DNA was quantified by quantitative PCR. Infectious virus was titered on Vero cells. CPXV-specific IgG was detected by ELISA. The patient had domestic rabbits, cats and dogs at home. Given the probability of contamination of the animals, PCR was performed on claws and plasmas samples from the animals; all results were negative. CPXV, cowpox virus; dpi, days postinfection; NA, not applicable; NT, not tested; TCID50, 50% tissue culture infectious dose; ++, medium level; +++, high level.

Main Article

1These authors are co–first authors.

Page created: July 30, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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