Volume 27, Number 10—October 2021
Research
Fatal Cowpox Virus Infection in Human Fetus, France, 2017
Audrey Ferrier1, Gaelle Frenois-Veyrat1, Evelyne Schvoerer, Sandrine Henard, Fanny Jarjaval, Isabelle Drouet, Hawa Timera, Laetitia Boutin, Estelle Mosca, Christophe Peyrefitte, and Olivier Ferraris
Table
Quantification of genomic or infectious CPXV in samples and CPXV-specific IgG detection in serum of mother and fetus, France, 2017*
| Samples | Jul 19, 29 dpi |
Jul 21, 31 dpi |
Aug 3, 44 dpi |
Aug 30, 71 dpi |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cutaneous biopsy | Plasma | Cutaneous biopsy | Fetus | Placenta | Vaginal swab | Plasma | Vaginal swab | Plasma | ||||
| DNA, copies/μL | 2.4×104 | 26.6 | 8.6 × 106 | 1.6 × 106 | 1.4 × 106 | 2.0 × 104 | – | 27 | – | |||
| Infectious virus, TCID50/mL | NT | – | 1.86 × 107 | 2.32 × 107 | 9.74 × 107 | 1.95 × 108 | – | – | – | |||
| CPXV-specific IgG | NA | ++ | NA | NA | NA | NA | ++ | NA | +++ | |||
*CPXV DNA was quantified by quantitative PCR. Infectious virus was titered on Vero cells. CPXV-specific IgG was detected by ELISA. The patient had domestic rabbits, cats and dogs at home. Given the probability of contamination of the animals, PCR was performed on claws and plasmas samples from the animals; all results were negative. CPXV, cowpox virus; dpi, days postinfection; NA, not applicable; NT, not tested; TCID50, 50% tissue culture infectious dose; ++, medium level; +++, high level.
1These authors are co–first authors.
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