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Volume 27, Number 10—October 2021

Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease

Patricia C. Cheung, A. Robin Eisch, Noble Maleque, Derek M. Polly, Sara C. Auld, and Kirk M. DrueyComments to Author 
Author affiliations: Emory University School of Medicine and Rollins School of Public Health, Atlanta, Georgia, USA (P.C. Cheung, N. Maleque, S.C. Auld); National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland, USA (A.R. Eisch, K.M. Druey); Emory University Hospital Midtown Department of Pharmacy, Atlanta (D.M. Polly)

Main Article

Table 2

Clinical characteristics of acute SCLS compared with severe COVID-19*

Parameter SCLS COVID-19
Blood pressure Low/undetectable, vasopressor-resistant Normal/high
Hgb/Hct Very elevated Normal/low
Serum albumin Very low Normal/low
Pulmonary findings Absent Lung infiltrates, tachypnea, hypoxemia
Edema Anasarca, compartment syndrome Pulmonary edema; no peripheral edema
Creatine kinase Very elevated Normal/elevated
Creatinine Elevated, acute kidney injury common Normal

*COVID-19, coronavirus disease; Hgb/Hct, hemoglobin/hematocrit ratio; SCLS, systemic capillary leak syndrome.

Main Article

Page created: July 15, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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