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Volume 27, Number 10—October 2021
Synopsis

Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease

Patricia C. Cheung, A. Robin Eisch, Noble Maleque, Derek M. Polly, Sara C. Auld, and Kirk M. DrueyComments to Author 
Author affiliations: Emory University School of Medicine and Rollins School of Public Health, Atlanta, Georgia, USA (P.C. Cheung, N. Maleque, S.C. Auld); National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland, USA (A.R. Eisch, K.M. Druey); Emory University Hospital Midtown Department of Pharmacy, Atlanta (D.M. Polly)

Main Article

Table 1

Laboratory values during hospitalization for case-patient 1 with systemic capillary leak syndrome and coronavirus disease*

Test Reference range Admission, 2021 Jan 31 Hospital floor, 2021 Feb 2 Hospital floor/ ICU, 2021 Feb 3 ICU, 
2021 Feb 4 ICU, 
2021 Feb 5
Albumin 3.5–5.7 g/dL 3.8 3.2 2.4 2.1 2.3
Hemoglobin 11.4–14.4 g/dL 17.1 20.3 17.4 14.5 8.7
Hematocrit 33.3%–41.4% 52.0 61.0 52.6 44.8 26.7
Creatinine 0.6–1.2 mg/dL 0.95 1.2 1.42 1.80 0.85a
Sodium 136–145 mmol/L 132 129 126 129 129
Potassium 3.5–5.1 mmol/L 4.3 4.7 5.6 6.1 6.5
Phosphate 2.5–5.0 mg/dL NA 6.1 5.1 6.9 8.0
Alanine transaminase 7–52 unit/L 32 26 92 299 7,928
Troponin ≤0.04 ng/mL 0.04 <0.03 NA 0.23 0.50
Creatine kinase 30–223 unit/L NA 1,851 15,094 41,696 >45,000
C-reactive protein ≤10 mg/L NA 12.8 42.2 41.8 58.1
Leukocytes 4.0–10.0 103/μL 7.0 9.7 19.5 25.3 12.6
Platelets 150–400 103/μL 184 158 145 170 71
Lactate 0.5–2.2 mmol/L 4.6 6.3 5.7 8.2 10.5
D-dimer ≤574 ng/mL 475 NA 1,016 1,271 9,536
International normalized ratio Not applicable NA 0.97 NA 1.23 3.29
Activated partial thromboplastin time 26.5–36.5 s NA NA NA NA 148.9
Complement C3 81–157 mg/dL NA NA NA 74 NA
Complement C4 13–39 mg/dL NA NA NA 22 NA

*ICU, intensive care unit; NA, not available

Main Article

Page created: July 15, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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