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Volume 27, Number 10—October 2021
Research

New Delhi Metallo-β-Lactamase–Producing Enterobacterales Bacteria, Switzerland, 2019–2020

Jacqueline Findlay, Laurent PoirelComments to Author , Julie Kessler, Andreas Kronenberg, and Patrice Nordmann
Author affiliations: University of Fribourg, Fribourg, Switzerland (J. Findlay, L. Poirel, J. Kessler, P. Nordmann); University of Bern, Bern, Switzerland (A. Kronenberg); Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland (P. Nordmann); Associate Editor, Emerging Infectious Diseases (P. Nordmann)

Main Article

Table 2

MIC distributions for 108 blaNDM-positive isolates identified in Enterobacterales bacteria, Switzerland, 2019–2020*

Antimicrobial drug Breakpoint MIC, mg/L
 No. isolates at MIC
 % Susceptible
S R <0.06 0.125 0.25 0.5 1 2 4 8 16 32 64 128 >256
Imipenem <2 >4 2 8 23 37 19 11 8 9.3
Imipenem/relebactam <2 >2 2 9 30 34 15 11 7 1.9
Meropenem <2 >2 8 9 15 27 25 20 4 0
Meropenem/vaborbactam <2 >8 8 9 19 27 25 19 1 15.7
Ceftazidime <1 >4 108† 0
Ceftazidime/avibactam <8 >8 108† 0
Aztreonam <1 >4 3 1 1 1 2 3 8 3 2 8 22 54 10.2
Aztreonam/avibactam‡ ≤4 >4§ 15¶ 19 16 14 12 11 13 4 4 92.6

*Testing range for all drugs was 0.06–256 mg/L. Breakpoints from the European Committee on Antimicrobial Susceptibility Testing. Gray shading indicates resistant isolates. R, resistant; S, susceptible. †MIC>256 mg/L. ‡Avibactam used at a fixed concentration of 4 mg/L. §Aztreonam/avibactam breakpoint selected arbitrarily based on the aztreonam breakpoints. ¶MIC<0.06 mg/L.

Main Article

Page created: August 12, 2021
Page updated: September 19, 2021
Page reviewed: September 19, 2021
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