Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 11—November 2021
Research

Hepatitis A Virus Incidence Rates and Biomarker Dynamics for Plasma Donors, United States

Stephanie Schoch, Martin Wälti, Mathias Schemmerer, Rick Alexander, Björn Keiner, Carol Kralicek, Keith Bycholski, Kelley Hyatt, Jon Knowles, Denis KlochkovComments to Author , Toby Simon, Jürgen J. Wenzel, Nathan J. Roth, and Eleonora Widmer
Author affiliations: CSL Behring AG, Bern, Switzerland (S. Schoch, M. Wälti, D. Klochkov, N.J. Roth, E. Widmer); University Medical Center Regensburg, Regensburg, Germany (M. Schemmerer, J.J. Wenzel); CSL Plasma, Knoxville, Tennessee, USA (R. Alexander); CSL Behring GmbH, Marburg, Germany (B. Keiner); CSL Plasma, Boca Raton, Florida, USA (K. Bycholski, K. Hyatt, J. Knowles, T. Simon); CSL Plasma, Dallas, Texas, USA (C. Kralicek)

Main Article

Figure 4

HAV biologic and clinical marker dynamics in plasma donors, United States. Quantitative HAV RNA and ALT results, as well as semiquantitative HAV IgM and IgG results, are shown for all 9 donors who seroconverted. Vertical dashed lines indicate day 0, the earliest collection date with detectable HAV RNA. Reactive nucleic acid testing results below the validated limit of detection of 14 IU/mL are not shown. The IgG result is defined as nonreactive/reactive for S/CO ratios <1 and ≥1, respectively. The IgM assay is defined as nonreactive/reactive for S/CO ratios <0.80 and >1.20, respectively, and as gray zone reactive for S/CO ratios of 0.80‒1.20. The results of a tenth donor (donor F) who had 1 confirmed weak-positive HAV RNA result and all nonreactive IgM/IgG results is not shown but is described in the Results. The figure illustrates the extensive individual variation in viremia curves and timing of biomarker events. ALT, alanine aminotransferase; HAV, hepatitis A virus; S/CO, signal-to-cutoff ratio.

Figure 4. HAV biologic and clinical marker dynamics in plasma donors, United States. Quantitative HAV RNA and ALT results, as well as semiquantitative HAV IgM and IgG results, are shown for all 9 donors who seroconverted. Vertical dashed lines indicate day 0, the earliest collection date with detectable HAV RNA. Reactive nucleic acid testing results below the validated limit of detection of 14 IU/mL are not shown. The IgG result is defined as nonreactive/reactive for S/CO ratios <1 and ≥1, respectively. The IgM assay is defined as nonreactive/reactive for S/CO ratios <0.80 and >1.20, respectively, and as gray zone reactive for S/CO ratios of 0.80‒1.20. The results of a tenth donor (donor F) who had 1 confirmed weak-positive HAV RNA result and all nonreactive IgM/IgG results is not shown but is described in the Results. The figure illustrates the extensive individual variation in viremia curves and timing of biomarker events. ALT, alanine aminotransferase; HAV, hepatitis A virus; S/CO, signal-to-cutoff ratio.

Main Article

Page created: August 02, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external