Population Genomics and Inference of Mycobacterium avium Complex Clusters in Cystic Fibrosis Care Centers, United States
Nabeeh A. Hasan1
, Rebecca M. Davidson1
, L. Elaine Epperson, Sara M. Kammlade, Sean Beagle, Adrah R. Levin, Vinicius Calado de Moura, Joshua J. Hunkins, Natalia Weakly, Scott D. Sagel, Stacey L. Martiniano, Max Salfinger, Charles L. Daley, Jerry A. Nick, and Michael Strong
Author affiliations: National Jewish Health, Denver, Colorado, USA (N.A. Hasan, R.M. Davidson, L.E. Epperson, S.M. Kammlade, S. Beagle, A.R. Levin, V. Calado de Moura, J.J. Hunkins, N. Weakly, C.L. Daley, J.A. Nick, M. Strong); University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado, Aurora, Colorado, USA (S.D. Sagel, S.L. Martiniano); University of South Florida College of Public Health and Morsani College of Medicine, Tampa, Florida, USA (M. Salfinger)
Figure 1. Cluster analysis of MAC in persons with cystic fibrosis to identify recent shared ancestry in a study of MAC clusters in cystic fibrosis centers, United States. A) Pairwise SNP distances of Mycobacterium avium and M. intracellulare subsp. chimaera, and M. intracellulare subsp. intracellulare isolates from within same patients (blue) and between different patients (red). B) Pairwise SNP distances of all CFCC MAC by state, CFCC, and patient comparisons. Kruskal–Wallis rank-sum test p values for comparing mean differences between categories are specified above each comparison. C) Pairwise SNP distances of CFCC MAC by state, CFCC, and patient comparisons under the clustering threshold. Box and scatterplots in panels B and C show SNPs between isolates at the same versus different states, same versus different CFCC, and same versus different patients. Horizontal lines within boxes indicate medians; top and bottom of boxes indicate 25th and 75th percentiles; error bars indicate the maximum and minimum values observed in the distribution. CFCC, cystic fibrosis care center; MAC, Mycobacterium avium complex; SNP, single-nucleotide polymorphism.
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