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Volume 27, Number 12—December 2021
Research

Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018

Neeltje van Doremalen1, Michael Letko1Comments to Author , Robert J. Fischer, Trenton Bushmaker, Jonathan Schulz, Claude K. Yinda, Stephanie N. Seifert, Nam Joong Kim, Maged G. Hemida, Ghazi Kayali, Wan Beom Park, Ranawaka A.P.M. Perera, Azaibi Tamin, Natalie J. Thornburg, Suxiang Tong, Krista Queen, Maria D. van Kerkhove, Young Ki Choi, Myoung-don Oh, Abdullah M. Assiri, Malik Peiris, Susan I. Gerber, and Vincent J. MunsterComments to Author 
Author affiliations: National Institutes of Health, Hamilton, Montana, USA (N. van Doremalen, M. Letko, R.J. Fischer, T. Bushmaker, J. Schulz, C.K. Yinda, S.N. Seifert, V.J. Munster); Washington State University, Pullman, Washington, USA (M. Leitko, S.N. Seifert); Seoul National University College of Medicine, Seoul, South Korea (N.J. Kim, W.B. Park, M.-d. Oh); King Faisal University, Al-Hasa, Saudi Arabia (M.G. Hemida); Kafrelsheikh University, Kafrelsheikh, Egypt (M.G. Hemida); University of Texas Health Sciences Center, Houston, Texas, USA (G. Kayali); University of Hong Kong, Hong Kong, China (R.A.P.M. Perera, M. Peiris); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A. Tamin, N.J. Thornburg, S. Tong, K. Queen, S.I. Gerber); World Health Organization, Geneva, Switzerland (M.D. van Kerkhove); Chungbuk National University, Cheongju City, South Korea (Y.K. Choi); Ministry of Health, Riyadh, Saudi Arabia (A.M. Assiri)

Main Article

Table

Characteristics of Middle East respiratory syndrome coronaviruses tested*

Name Host Year Location Full name GenBank accession no. SNPs >50%
EMC/12
Human
2012
Saudi Arabia
HCoV-EMC/2012
JX869059
G27162A (ORF5, W108†)
U/14
Human
2014
United States
Hu/Florida/USA-2/Saudi Arabia/2014
KP223131
None
KSA/15
Human
2015
Saudi Arabia
Hu/Hofuf/KSA-11002/2015
KY688120
None
SK/15
Human
2015
South Korea
Hu/Korea/Seoul/177–3/2015
KX034100
C2149A (NSP2, S431Y); A6884G (synonymous); T9566C (synonymous); G10155T (NSP5, A46S); A11376T (NSP6, S147C); C14162T (synonymous); C26189T (ORF4b R33C)
KSA/18
Human
2018
Saudi Arabia
Hu/Saudi Arabia/3015600912/2018
MN723544
C21149A (NSP16, L183I); G22366A† (S, R304Q); C25009T (S, S1185L)
C/KSA/13
Camel
2013
Saudi Arabia
Camel/Saudi Arabia/KFU-HKU1/2013
KJ650297
C25207T (S, S1251F); C27875T (M, T8I)
C/E/13
Camel
2013
Egypt
Camel/Egypt/NRCE/HKU270/2013
KJ477103
T16318C (synonymous); C24112T (S, A886V); 26892T (ORF5, P18L)
C/BF/15 Camel 2015 Burkina Faso Camel/Burkina Faso/CIRAD-HKU785/2015 MG923471 None

*NSP, nonstructural protein; ORF, open reading frame; SNP, single-nucleotide polymorphism. †Present in other sequences.

Main Article

1These authors contributed equally to this article.

Page created: August 26, 2021
Page updated: November 19, 2021
Page reviewed: November 19, 2021
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