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Volume 27, Number 12—December 2021
Research

Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017

Melanie M. Hierweger, Michel C. Koch, Melanie Rupp, Piet Maes, Nicholas Di Paola, Rémy Bruggmann, Jens H. Kuhn, Heike Schmidt-Posthaus1, and Torsten Seuberlich1Comments to Author 
Author affiliations: University of Bern, Bern, Switzerland (M.M. Hierweger, M.C. Koch, M. Rupp, R. Bruggmann, H. Schmidt-Posthaus, T. Seuberlich); KU Leuven, Leuven, Belgium (P. Maes); US Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA (N. Di Paola); Integrated Research Facility at Fort Detrick, Frederick (J. H. Kuhn)

Main Article

Figure 4

Histopathologic lesions and viral RNA in European perch infected with Bern perch virus. A) Histopathologic lesions in gills (hematoxylin and eosin stain) showing epithelial hypertrophy and hyperplasia, multifocally leading to lamellar fusion (stars) and multifocal epithelial lifting due to edema (closed arrowheads). Scale bar indicates 25 μm. B) In situ hybridization detection of Bern perch virus RNA in gills (brown labeling): positive macrophages, more pronounced in proliferated areas, and endothelial cells. Inset: higher magnification showing positive macrophages (open arrowheads) and endothelial cells (arrows with open heads). Scale bar indicates 50 μm.

Figure 4. Histopathologic lesions and viral RNA in European perch infected with Bern perch virus. A) Histopathologic lesions in gills (hematoxylin and eosin stain) showing epithelial hypertrophy and hyperplasia, multifocally leading to lamellar fusion (stars) and multifocal epithelial lifting due to edema (closed arrowheads). Scale bar indicates 25 μm. B) In situ hybridization detection of Bern perch virus RNA in gills (brown labeling): positive macrophages, more pronounced in proliferated areas, and endothelial cells. Inset: higher magnification showing positive macrophages (open arrowheads) and endothelial cells (arrows with open heads). Scale bar indicates 50 μm.

Main Article

1These authors contributed equally to this article.

Page created: October 06, 2021
Page updated: November 22, 2021
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