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Volume 27, Number 12—December 2021

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020

Maximilian Stich1, Roland Elling1, Hanna Renk1, Aleš Janda1, Sven F. Garbade, Barbara Müller, Hans-Georg Kräusslich, Dorit Fabricius, Maria Zernickel, Peter Meissner, Daniela Huzly, Jürgen Grulich-Henn, Anneke Haddad, Tessa Görne, Benedikt Spielberger, Linus Fritsch, Alexandra Nieters, Hartmut Hengel, Andrea N. Dietz, Thomas Stamminger, Tina Ganzenmueller, Natalia Ruetalo, Andreas Peter, Jonathan Remppis, Thomas Iftner, Kathrin Jeltsch, Tim Waterboer, Axel R. Franz, Georg Friedrich Hoffmann, Corinna Engel2, Klaus-Michael Debatin2, Burkhard Tönshoff2Comments to Author , and Philipp Henneke2
Author affiliations: Heidelberg University Hospital, Heidelberg, Germany (M. Stich, S.F. Garbade, B. Müller, H.-G. Kräusslich, J. Grulich-Henn, K. Jeltsch, G.F. Hoffmann, B. Tönshoff); University Medical Centre and Faculty of Medicine Freiburg, Freiburg, Germany (R. Elling, D. Huzly, A. Haddad, T. Görne, B. Spielberger, L. Fritsch, A. Nieters, H. Hengel, P. Henneke); University Hospital and Faculty of Medicine Tübingen, Tübingen, Germany (H. Renk, T. Ganzenmueller, N. Ruetalo, A. Peter, J. Remppis, T. Iftner, A.R. Franz, C. Engel); Ulm University Medical Center, Ulm, Germany (A. Janda, D. Fabricius, M. Zernickel, P. Meissner, A.N. Dietz, T. Stamminger, K.-M. Debatin); German Cancer Research Center (DKFZ), Heidelberg (T. Waterboer)

Main Article

Table 3

Association between coronavirus disease–related symptoms or hospitalization in index case-patients and secondary attack rates in exposed household members from 393 households with a symptomatic index case-patient whose hospitalization status is known, southwest Germany, May–August 2020*

Index case symptom or hospitalization No. index cases, n = 393 No. exposed, n = 1182 No. seropositive
exposed, n = 390
Observed SAR, % Predicted SAR, % (IQR)† Odds ratio (95% CI)† p value†
Fever 225 666 253 38.0 36.8 (11.8–58.4) 1.93 (1.14–3.31) 0.015
Cough 236 717 272 37.9 36.8 (11.7–58.2) 2.07 (1.21–3.53) 0.008
Diarrhea 91 271 94 34.7 33.2 (9.34–54.5) 0.80 (0.43–1.49) 0.481
32.2 (10.4–48.7)
1.41 (0.82–2.43)
Hospitalization 22 67 30 44.8 43.9 (15.2–68.9) 1.22 (0.40–3.75) 0.726

*IQR, interquartile range; NA, not applicable; SAR, secondary attack rate. †The predicted SARs, odds ratios, and p values were calculated from a multivariable generalized linear mixed-effects logistic regression model. The respective references were absence of the symptom or “hospitalization” and adjusted for age of index case-patient as a numeric variable (OR 1.04, 95% CI 1.01–1.06; p = 0.0055).

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: September 16, 2021
Page updated: November 19, 2021
Page reviewed: November 19, 2021
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