Table 2

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020

Maximilian Stich¹, Roland Elling¹, Hanna Renk¹, Aleš Janda¹, Sven F. Garbade, Barbara Müller, Hans-Georg Kräusslich, Dorit Fabricius, Maria Zernickel, Peter Meissner, Daniela Huzly, Jürgen Grulich-Henn, Anneke Haddad, Tessa Görne, Benedikt Spielberger, Linus Fritsch, Alexandra Nieters, Hartmut Hengel, Andrea N. Dietz, Thomas Stamminger, Tina Ganzenmueller, Natalia Ruetalo, Andreas Peter, Jonathan Remppis, Thomas Iftner, Kathrin Jeltsch, Tim Waterboer, Axel R. Franz, Georg Friedrich Hoffmann, Corinna Engel², Klaus-Michael Debatin², Burkhard Tönshoff²

, and Philipp Henneke²

Author affiliations: Heidelberg University Hospital, Heidelberg, Germany (M. Stich, S.F. Garbade, B. Müller, H.-G. Kräusslich, J. Grulich-Henn, K. Jeltsch, G.F. Hoffmann, B. Tönshoff); University Medical Centre and Faculty of Medicine Freiburg, Freiburg, Germany (R. Elling, D. Huzly, A. Haddad, T. Görne, B. Spielberger, L. Fritsch, A. Nieters, H. Hengel, P. Henneke); University Hospital and Faculty of Medicine Tübingen, Tübingen, Germany (H. Renk, T. Ganzenmueller, N. Ruetalo, A. Peter, J. Remppis, T. Iftner, A.R. Franz, C. Engel); Ulm University Medical Center, Ulm, Germany (A. Janda, D. Fabricius, M. Zernickel, P. Meissner, A.N. Dietz, T. Stamminger, K.-M. Debatin); German Cancer Research Center (DKFZ), Heidelberg (T. Waterboer)

Main Article

Secondary attack rates in household members exposed to severe acute respiratory syndrome coronavirus 2 from 405 households, southwest Germany, May–August 2020*

Characteristic	No. index cases	No. exposed	No. seropositive exposed	Observed SAR, %	Predicted SAR, % (IQR)†	Odds ratio  (95% CI)	p value
No. participants	405	1,220	400	32.8	31.6 (8.31–52.2)	NA	NA
Age of index case-patients, y
>60	6	21	15	71.4	72.9 (54.9–88.9)	9.02 (1.19–72.8)	0.039
18.0–59.9	374	1122	366	32.6	31.3 (8.41–51.1)	Referent
12.0–17.9	16	47	15	31.9	30.8 (3.11–55.9)	1.32 (0.31–5.57)	0.704
0.0–11.9	9	30	4	13.3	12.0 (0.59–11.4)	0.34 (0.04–3.19)	0.343
Age of exposed household members, y
>18	NA	542	206	38.0	37.5 (13.2–59.4)	Referent
12.0–17.9	NA	244	68	27.9	25.8 (6.24–40.2)	0.39 (0.25–0.63)	<0.001
6.0–11.9	NA	257	79	30.7	29.2 (8.02–47.9)	0.55 (0.35–0.89)	0.015
0.0–5.9	NA	177	47	26.6	24.6 (5.09–43.8)	0.33 (0.18–0.58)	<0.001
Sex of index case-patients
M	207	629	213	33.9	32.6 (8.52–53.6)	Referent
F	198	591	187	31.6	30.4 (8.12–50.8)	1.07 (0.62–1.87)	0.803
Sex of exposed household members
M	NA	600	195	32.5	31.1 (7.62–51.9)	Referent
F	NA	620	205	33.1	31.9 (8.54–53.5)	1.08 (0.75–1.56)	0.676
Household size
2–3	92	175	69	39.4	38.1 (12.5–67.1)	Referent
4	206	598	185	30.9	29.4 (8.26–44.0)	0.50 (0.24–1.01)	0.055
5	75	285	98	34.4	33.5 (8.57–53.7)	0.77 (0.33–1.78)	0.543
>6	32	162	48	29.6	28.8 (4.64–55.6)	0.40 (0.14–1.18)	0.095
SARS-CoV-2–seropositive index case-patient
No	42	130	7	5.38	3.59 (0.71–2.17)	Referent
Yes	363	1090	393	36.1	34.9 (12.0–56.4)	27.8 (8.26–93.5)	<0.001

*IQR, interquartile range; NA, not applicable; SAR, secondary attack rate. †The predicted SARs, odds ratios, and p values were calculated from a multivariable generalized linear mixed-effects logistic regression model. The respective references were “adult index 18.0-59.9 years,” “adult exposed,” “male index,” “male exposed,” “household size 2–3,” and “seronegative index.”

Main Article

¹These first authors contributed equally to this article.

²These senior authors contributed equally to this article.

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