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Volume 27, Number 2—February 2021
Research

Plasma MicroRNA Profiling of Plasmodium falciparum Biomass and Association with Severity of Malaria Disease

Himanshu Gupta12Comments to Author , Mercedes Rubio1, Antonio Sitoe, Rosauro Varo, Pau Cisteró, Lola Madrid, Inocencia Cuamba, Alfons Jimenez, Xavier Martiáñez-Vendrell, Diana Barrios, Lorena Pantano, Allison Brimacombe, Mariona Bustamante, Quique Bassat3, and Alfredo Mayor3
Author affiliations: ISGlobal, Hospital Clinic—Universitat de Barcelona, Barcelona, Spain (H. Gupta, M. Rubio, R. Varo, P. Cisteró, A. Jimenez, X. Martiáñez-Vendrell, D. Barrios, A. Brimacombe, M. Bustamante, Q. Bassat, A. Mayor); Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique (A. Sitoe, R. Varo, L. Madrid, I. Cuamba, Q. Bassat, A. Mayor); Spanish Consortium for Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (A. Jimenez, M. Bustamante, Q. Bassat, A. Mayor); Harvard T.H. Chan School of Public Health Department of Biostatistics, Boston, Massachusetts, USA (L. Pantano); Universitat Pompeu Fabra (UPF), Barcelona (M. Bustamante); I; nstitut Català de Recerca en Estudis Avançats (ICREA), Barcelona (Q. Bassat); Hospital Sant Joan de Déu—University of Barcelona Pediatrics Department, Barcelona (Q. Bassat)

Main Article

Figure 1

Schematic representation of study design to identify miRNA-based biomarkers of SM among children with malaria, Mozambique. ePCR, endothelial protein-C receptor (a binding Plasmodium falciparum strain-FCR3); HRP2, histidine-rich protein 2; iE, infected erythrocyte; miRNA, microRNA; niE, noninfected erythrocyte; SM, severe malaria; SS, severity symptoms; UM, uncomplicated malaria; 3D7, a nonbinding P. falciparum strain.

Figure 1. Schematic representation of study design to identify miRNA-based biomarkers of SM. ePCR, endothelial protein-C receptor (a binding Plasmodium falciparum strain-FCR3); HRP2, histidine-rich protein 2; iE, infected erythrocyte; miRNA, microRNA; niE, noninfected erythrocyte; SM, severe malaria; SS, severity symptoms; UM, uncomplicated malaria; 3D7, a nonbinding P. falciparum strain.

Main Article

1These authors contributed equally to this article.

2Current affiliation: London School of Hygiene and Tropical Medicine, London, UK.

3These senior authors contributed equally to this article.

Page created: December 10, 2020
Page updated: January 23, 2021
Page reviewed: January 23, 2021
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