Volume 27, Number 2—February 2021
Plasma MicroRNA Profiling of Plasmodium falciparum Biomass and Association with Severity of Malaria Disease
|Characteristic||miRNA||baseMean||log2-fold change||Adjusted p value|
|SM, n = 44 vs. 39 UM|
|SA, n = 17 vs. 39 UM|
|Prostration, n = 33 vs. 39 UM|
|Acidosis or respiratory distress, n = 18 vs. 39 UM|
|Platelet-mediated agglutination, n = 50 vs. 19 UM|
|gC1qR, n = 35 vs. 34 UM|
*Positive fold change indicates overexpression in severe malaria and symptoms of severity compared to UM as well as parasites showing cytoadhesion compared to none. Total number of miRNAs in RNA sequencing data was 1,450. p value adjusted for multiple testing by the Benjamini-Hochberg method. baseMean, mean normalized expression of the miRNAs in all the samples; miRNA, microRNA; SA, severe anemia, SM, severe malaria; UM, uncomplicated malaria.
1These authors contributed equally to this article.
2Current affiliation: London School of Hygiene and Tropical Medicine, London, UK.
3These senior authors contributed equally to this article.