Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 3—March 2021
Research

Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016

Nicola M. ZetolaComments to Author , Patrick K. Moonan, Eleanor Click, John E. Oeltmann, Joyce Basotli, Xiao-Jun Wen, Rosanna Boyd, James L. Tobias, Alyssa Finlay1, and Chawangwa Modongo1
Author affiliations: University of Pennsylvania Partnership, Philadelphia, Pennsylvania, USA (N.M. Zetola, C. Modongo); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.K. Moonan, E. Click, J.E. Oeltmann, J. Basotli, X.-J. Wen, R. Boyd, J.L. Tobias, A. Finlay)

Main Article

Table 3

Characteristics associated with localized tuberculosis transmission venues for population-based geospatial and molecular epidemiologic study of tuberculosis transmission dynamics, Botswana, 2012–2016*

Characteristic Member of localized TB transmission, n = 780 Not a member of localized TB transmission, n = 1,016 Adjusted odds ratio (95% CI)
Sex
M 436 (55.9) 555 (54.6) 1.05 (0.87–1.27)
F
 334 (44.1)
 461 (45.4)
Age, y
<15 26 (3.3) 18 (1.8) 2.20 (1.67–4.15)
16–24 157 (20.1) 170 (16.7) 1.41 (1.05–1.89)
25–40 418 (53.6) 558 (54.9) 1.14 (0.90–1.45)
41–64 158 (20.3) 241 (23.7) Referent
>65
 21 (2.7)
 29 (2.9)
 1.11 (0.61–3.00)
Resided in high-burden geographic area† 291 (37.1) 181 (17.8) 2.75 (2.21–3.41)
Excessive alcohol use‡ 160 (20.6) 205 (20.2) 1.03 (0.82–1.30)
Current smoker 250 (32.1) 220 (21.7) 1.71 (1.38–2.11)
Unemployed 314 (41.6) 352 (35.3) 1.31 (1.08–1.59)
History of incarceration 49 (6.3) 56 (5.5) 1.15 (0.78–1.71)
HIV positive 366 (48.5) 570 (57.2) 0.71 (0.58–0.85)
Previous TB episode 156 (20.0) 178 (17.5) 1.17 (0.93–1.49)

*Values are no. (%). Bold indicates statistical significance at α = 0.05. Localized transmission defined by SaTScan (https://www.satscan.org)–identified geographic areas with a larger-than-expected rate of unique genotype clustering compared with all other culture-positive TB patients as the background rate; excludes 128 patients with valid genotype results and no residential address. TB, tuberculosis.
†Residing in a geographic area with an estimated annualized TB incidence > 305 patients/100,000 persons.
‡Five or more drinks/session in the previous 30 d or drinking on >5 days in the previous 30 d.

Main Article

1These senior authors contributed equally to this article.

Page created: December 03, 2020
Page updated: February 21, 2021
Page reviewed: February 21, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external