Volume 27, Number 3—March 2021
Research
Population-Based Geospatial and Molecular Epidemiologic Study of Tuberculosis Transmission Dynamics, Botswana, 2012–2016
Nicola M. Zetola
, Patrick K. Moonan, Eleanor Click, John E. Oeltmann, Joyce Basotli, Xiao-Jun Wen, Rosanna Boyd, James L. Tobias, Alyssa Finlay1, and Chawangwa Modongo1
, Patrick K. Moonan, Eleanor Click, John E. Oeltmann, Joyce Basotli, Xiao-Jun Wen, Rosanna Boyd, James L. Tobias, Alyssa Finlay1, and Chawangwa Modongo1
Table 2
Demographic and clinical characteristics by geographic area venues for population-based geospatial and molecular epidemiologic study of tuberculosis transmission dynamics, Botswana, 2012–2016*
| Area | Population† | Size, km2 | Population density† | No. enrolled TB patients | No. who had TB (95% CI)‡ | No. (%) enrolled HIV-positive patients | No. Mycobacterium tuberculosis genotypes§ |
|---|---|---|---|---|---|---|---|
| Gaborone | |||||||
| A | 19,143 | 1.4 | 13,973 | 370 | 483 (438–536) | 245 (66.2) | 107 |
| B | 32,805 | 21.8 | 1,505 | 183 | 139 (121–161) | 109 (59.6) | 71 |
| C | 59,100 | 16.0 | 3,694 | 591 | 250 (231–271) | 379 (64.1) | 168 |
| D | 51,190 | 53.9 | 950 | 574 | 280 (259–305) | 364 (63.4) | 170 |
| E | 34,262 | 39.5 | 867 | 249 | 182 (161–206) | 165 (66.3) | 97 |
| F | 71,957 | 27.5 | 2,617 | 388 | 135 (122–149) | 243 (62.6) | 148 |
| G | 28,639 | 17.9 | 1,600 | 139 | 121 (104–144) | 79 (56.8) | 64 |
| H | 12,094 | 24.6 | 492 | 71 | 147 (117–185) | 54 (76.1) | 26 |
| I | 7,677 | 77.7 | 99 | 28 | 91 (63–132) | 17 (60.7) | 14 |
| J | 8,729 | 88.2 | 99 | 23 | 66 (44–99) | 17 (73.9) | 7 |
| K |
14,104 |
72.4 |
195 |
43 |
76 (58–105) |
34 (79.1) |
16 |
| Ghanzi District | |||||||
| W | 12,179 | 45.8 | 266 | 419 | 860 (783–945) | 158 (37.7) | 80 |
| DK | 1,668 | 9.7 | 172 | 73 | 1,094 (874–1,369) | 17 (23.3) | 16 |
| KU | 833 | 7.5 | 111 | 38 | 1,140 (836–1,556) | 16 (42.1) | 9 |
| Y | 2,203 | 1,607 | 1.3 | 193 | NA | 68 (35.2) | 45 |
| Other location |
354 |
NA |
NA |
354 |
NA |
221 (62.4) |
89 |
| Not geocoded |
NA |
NA |
NA |
595 |
NA |
366 (61.5) |
100 |
| Total | 354,380 | NA | NA | 4,331 | 306 (228–339) | 2,552 (58.9) | 686 |
*NA, not applicable; TB, tuberculosis. †Persons residing/km2. Based 2011 Population and Housing Census. Statistics Botswana. ‡TB incidence/100,000 persons; 95% CIs assume a Poisson distribution);based on no. cases enrolled from each geography divided by the population estimates for each geography annualized to the duration of study period. §Rows are not mutually exclusive; strains might be found in multiple locations.
1These senior authors contributed equally to this article.
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