Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan
Amyn A. Malik

, Neel R. Gandhi, Timothy L. Lash, Lisa M. Cranmer, Saad B. Omer, Junaid F. Ahmed, Sara Siddiqui, Farhana Amanullah, Aamir J. Khan, Salmaan Keshavjee, Hamidah Hussain
1, and Mercedes C. Becerra
1
Author affiliations: Emory University Rollins School of Public Health, Atlanta, Georgia, USA (A.A. Malik, N.R. Gandhi, T.L. Lash); Yale University, New Haven, Connecticut, USA (A.A. Malik, S.B. Omer); Global Health Directorate, Indus Health Network, Karachi, Pakistan (A.A. Malik, J.F. Ahmed, S. Siddiqui); Interactive Research and Development, Singapore (A.A. Malik, A.J. Khan, H. Hussain); Emory University School of Medicine, Atlanta (N.R. Gandhi, L.M. Cranmer); Emory + Children’s Pediatric Institute, Atlanta (L.M. Cranmer); The Indus Hospital, Karachi (F. Amanullah); Harvard University, Cambridge, Massachusetts, USA (A.J. Khan, S. Keshavjee, M.C. Becerra); Partners In Health, Boston, Massachusetts, USA (S. Keshavjee, M.C. Becerra); Brigham and Women’s Hospital, Boston (S. Keshavjee, M.C. Becerra)
Main Article
Table 1
Preventive therapy regimens in study of persons exposed at home to drug-resistant tuberculosis, Karachi, Pakistan, February 2016–March 2017*
Regimen |
Drug 1, dose |
Drug 2, dose |
Levofloxacin/ethambutol
|
Levofloxacin, <5 y: 15–20 mg/kg, >5 y: 7.5–10 mg/kg; max. dose 1,000 mg/d
|
Ethambutol, 15–25 mg/kg; max. dose 2,000 mg/kg
|
Levofloxacin/ethionamide
|
Levofloxacin, <5 y: 15–20 mg/kg, >5 y: 7.5–10 mg/kg; max. dose 1,000 mg/d
|
Ethionamide, 15–20 mg/kg; max. dose 750 mg/kg
|
Moxifloxacin/ethambutol
|
Moxifloxacin, 7.5–10 mg/kg; max. dose 400 mg/d
|
Ethambutol, 15–25 mg/kg; max. dose 2,000 mg/kg
|
Moxifloxacin/ethionamide
|
Moxifloxacin, 7.5–10 mg/kg; max. dose 400 mg/d
|
Ethionamide, 15–20 mg/kg; max. dose 750 mg/kg
|
*Max., maximum. |
Main Article
Page created: January 11, 2021
Page updated: February 19, 2021
Page reviewed: February 19, 2021
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