Volume 27, Number 3—March 2021
CME ACTIVITY - Research
Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan
Table 4
Incidence rate comparison of effectiveness of preventive therapy for tuberculosis in published studies in study of persons exposed at home to drug-resistant tuberculosis, Karachi, Pakistan*
Characteristic | Becerra et al. (25) | Fox et al. (22) | Reichler et al. (26) | Martin-Sanchez et al. (27) |
---|---|---|---|---|
No. expected cases | 4.7 | 3.9 | 6.6 | 6.6 |
Expected IR per 1,000 p-y | 15 | 12 | 20 | 20 |
IRR (95% CI) | 0.40 (0.05–2.0) | 0.50 (0.06–2.8) | 0.29 (0.04–1.3) | 0.29 (0.04–1.3) |
IR difference per 1,000 p-y (95% CI) | −8.0 (–23.0 to 7.1) | −5.7 (–20.0 to 8.5) | −14 (–31.0 to 3.4) | −14 (–31.0 to 3.4) |
NNT | 64 | 91 | 37 | 37 |
Preventive fraction in exposed, % | 57.5 | 48.7 | 69.5 | 69.7 |
*IR, incidence rate; IRR, incidence rate ratio; NNT, number needed to treat; p-y, person-years.
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1These authors contributed equally to this article.