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Volume 27, Number 3—March 2021
Research

Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014–2017

Ditthawat Nonghanphithak, Angkana Chaiprasert, Saijai Smithtikarn, Phalin Kamolwat, Petchawan Pungrassami, Virasakdi Chongsuvivatwong, Surakameth Mahasirimongkol, Wipa Reechaipichitkul, Chaniya Leepiyasakulchai, Jody E. Phelan, David Blair, Taane G. Clark, and Kiatichai FaksriComments to Author 
Author affiliations: Khon Kaen University, Khon Kaen, Thailand (D. Nonghanphithak, W. Reechaipichitkul, K. Faksri); Mahidol University, Bangkok, Thailand (A. Chaiprasert, C. Leepiyasakulchai); Ministry of Public Health, Bangkok (S. Smithtikarn, P. Kamolwat, P. Pungrassami); Prince of Songkla University, Hat Yai, Songkhla, Thailand (V. Chongsuvivatwong); Ministry of Public Health, Nonthaburi, Thailand (S. Mahasirimongkol); London School of Hygiene and Tropical Medicine, London, UK (J.E. Phelan, T.G. Clark); James Cook University, Townsville, Queensland, Australia (D. Blair)

Main Article

Figure 2

Phylogenetic tree for the 590 drug-resistant Mycobaterium tuberculosis isolates from Thailand, 2014–2017. From inner to the outer circles: culture-based phenotypic drug-susceptibility test, whole-genome sequencing–based drug-resistance profile (DR TB, MDR TB, pre-XDR TB, and XDR TB), drug-resistance mutations, lineage, year of collection, regions, and provinces. Red triangles indicate the paired isolates from the same patients (n = 11). Scale bar indicates the genetic distance proportional to the total number of single nucleotide polymorphisms. M. canetti was used as an outgroup. DR TB, drug-resistant tuberculosis; MDR, multidrug resistant; TB, tuberculosis; XDR, extensively drug-resistant.

Figure 2. Phylogenetic tree for the 590 drug-resistant Mycobaterium tuberculosis isolates from Thailand, 2014–2017. From inner to the outer circles: culture-based phenotypic drug-susceptibility test, whole-genome sequencing–based drug-resistance profile (DR TB, MDR TB, pre-XDR TB, and XDR TB), drug-resistance mutations, lineage, year of collection, regions, and provinces. Red triangles indicate the paired isolates from the same patients (n = 11). Scale bar indicates the genetic distance proportional to the total number of single nucleotide polymorphisms. M. canetti was used as an outgroup. DR TB, drug-resistant tuberculosis; MDR, multidrug resistant; TB, tuberculosis; XDR, extensively drug-resistant.

Main Article

Page created: December 29, 2020
Page updated: February 21, 2021
Page reviewed: February 21, 2021
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