Volume 27, Number 4—April 2021
Research
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci
Mingliang Chen1
, Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min Chen , and Martin C.J. Maiden
, Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min Chen , and Martin C.J. Maiden
Table 4
Potential donors of horizontal gene transfer events associated with contiguous unique loci in sublineage 44.1 of clonal complex 4821 of Neisseria meningitidis*
| Event | Donor strain (serogroup: ST) | Clonal complex | Country (year) | PubMLST ID | Fragment size, bp | Position† | NEIS no. unique locus |
|---|---|---|---|---|---|---|---|
| 1 | Nm281 (W: ST9486) | CC174 | China (1977) | 19343 | 2,369 | 1–2369 | NEIS2139, NEIS2140, NEIS2141 |
| 2 | Nm284 (E: ST9500) | Singleton | China (1977) | 19394 | 5,188 | 20775–25962 | NEIS0007, NEIS0008 |
| 3 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 3,242 | 27345–30586 | NEIS0009 |
| 4 | Nm420815 (X: ST5586) | Singleton | China (2008) | 85974 | 5,329 | 114259–119587 | NEIS2052, NEIS2050, NEIS2049 |
| 5 | Nm252 (B: ST1790) | CC41/44 | China (1976) | 26654 | 9,627 | 210681–220307 | NEIS1972, NEIS1968, NEIS1967, NEIS1966 |
| 6 | Nm284 (E: ST9500) | Singleton | China (1977) | 19394 | 3,886 | 244692–248577 | NEIS1956, NEIS2479, NEIS1954, NEIS1952 |
| 7 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 2,180 | 282425–284604 | NEIS1916, NEIS1915, NEIS1914 |
| 8 | BZ 232 (B: ST38) | CC37 | The Netherlands (1964) | 410 | 4,349 | 313176–317524 | NEIS0313, NEIS0314 |
| 9 | Nm289 (C: ST4822) | ST9514 cluster | China (1977) | 19721 | 5,828 | 321318–327145 | NEIS0320, NEIS0321, NEIS0323 |
| 10 | Nm259 (B: ST17) | Singleton | China (1977) | 26658 | 5,885 | 341967–347851 | NEIS0340, NEIS0341, NEIS0342 |
| 11 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 1,371 | 360040–361410 | NEIS0355, NEIS0356 |
| 12 | NmNX21 (B: ST5655) | CC8 | China (1987) | 86022 | 5,346 | 365048–370393 | NEIS0363 |
| 13 | NmHE89009 (B: ST5642) | Singleton | China (1989) | 86012 | 3,549 | 372802–376350 | NEIS0367, NEIS0370 |
| 14 | NmHE89009 (B: ST5642) | Singleton | China (1989) | 86012 | 1,076 | 383868–384943 | NEIS0375 |
| 15 | Nm218 (B: ST10385) | Singleton | China (1976) | 26633 | 3,652 | 386208–389859 | NEIS0378, NEIS0379 |
| 16 | W10470 (Y: ST4545) | Singleton | South Africa (2017) | 59858 | 3,819 | 410887–414705 | NEIS0394, NEIS0395, NEIS0396 |
| 17 | Nm148 (B: ST32) | CC32 | China (1967) | 26613 | 1,532 | 479638–481169 | NEIS0458, NEIS0459 |
| 18 | 200067 (B: ST3088) | CC35 | Bangladesh (2009) | 94107 | 1,602 | 481200–482801 | NEIS0462 |
| 19 | Nm279 (C: ST9506) | ST9514 cluster | China (1977) | 19400 | 7,850 | 573877–581726 | NEIS0548, NEIS0550, NEIS0551, NEIS0553, NEIS0555 |
| 20 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 3,860 | 595670–599529 | NEIS0567, NEIS0569, NEIS0570 |
| 21 | P15 (B: ST32) | CC32 | Norway (1969) | 26056 | 8,751 | 609318–618068 | NEIS0581, NEIS0582, NEIS0583, NEIS0586 |
| 22 | Nm441102 (B: ST8929) | Singleton | China (2010) | 85986 | 10,176 | 632301–642476 | NEIS0612, NEIS3022, NEIS0613, NEIS0615, NEIS0617, NEIS0618, NEIS0619, NEIS0620 |
| 23 | 9281 (C: ST8447) | CC175 | South Africa (2003) | 40583 | 8,269 | 657348–665616 | NEIS0641, NEIS0643, NEIS0644, NEIS0645, NEIS0649 |
| 24 | Nm279 (C: ST9506) | ST9514 cluster | China (1977) | 19400 | 6,236 | 704873–711108 | NEIS0685, NEIS0686, NEIS0689, NEIS0690 |
| 25 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 4,663 | 725942–730604 | NEIS0711, NEIS0713, NEIS0714 |
| 26 | 11–004 (A: ST5) | CC5 | China (1984) | 82 | 5,393 | 739214–744606 | NEIS0723, NEIS0724, NEIS0729, NEIS0730 |
| 27 | 61106 (A: ST1) | CC1 | Niger (1961) | 34552 | 8,069 | 739627–747695 | NEIS0731, NEIS0733 |
| 28 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 2,412 | 1038607–1041018 | NEIS1076, NEIS1078 |
| 29 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 16,089 | 1091594–1107682 | NEIS1127, NEIS1128, NEIS1129, NEIS1131, NEIS3081, NEIS1132, NEIS1133, NEIS1134, NEIS1137, NEIS1138, NEIS1139 |
| 30 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 10,667 | 1130089–1140755 | NEIS1160, NEIS1165, NEIS1168 |
| 31 | M10 240614 (B: ST9817) | singleton | UK (2010) | 20020 | 2,533 | 1198534–1201066 | NEIS1229, NEIS1231, NEIS1232, NEIS1233 |
| 32 | C10695 (cnl: new ST) | CC1136 | South Africa (2017) | 59854 | 1,852 | 1491092–1492943 | NEIS1479, NEIS1480 |
| 33 | Nm279 (C: ST9506) | ST9514 cluster | China (1977) | 19400 | 4,194 | 1585327–1589520 | NEIS1568, NEIS1570, NEIS1571 |
| 34 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 4,306 | 1611638–1615943 | NEIS1590, NEIS3123, NEIS1594 |
| 35 | NM320 (B: ST9513) | Singleton | China (1977) | 19407 | 1,618 | 1630175–1631792 | NEIS1605 |
| 36 | NmGZ80028 (A: ST3) | CC1 | China (1974) | 86004 | 9,784 | 1644769–1654552 | NEIS1618, NEIS1619, NEIS1622, NEIS1624, NEIS1629, NEIS1630 |
| 37 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 1,537 | 1674337–1675873 | NEIS1647 |
| 38 | 8044 (C: new ST) | Singleton | South Africa (2002) | 40541 | 3,081 | 1675114–1678194 | NEIS1649, NEIS1650 |
| 39 | Nm279 (C: ST9506) | ST9514 cluster | China (1977) | 19400 | 3,799 | 1840253–1844051 | NEIS1819, NEIS1820, NEIS1822, NEIS1824 |
| 40 | Nm140 (B: S-351) | Singleton | China (1967) | 26610 | 2,696 | 1926888–1929583 | NEIS0264, NEIS0261, NEIS0260 |
| 41 | 6183 (C: ST13352) | Singleton | South Africa (2001) | 40534 | 3,884 | 1930185–1934068 | NEIS0257 |
| 42 | NmGZ80028 (A: ST3) | CC1 | China (1974) | 86004 | 2,392 | 2076119–2078510 | NEIS0108, NEIS0107 |
| 43 | Nm280 (C: ST9514) | ST9514 cluster | Chna (1977) | 52352 | 6,321 | 2079333–2085653 | NEIS0105, NEIS0104, NEIS3165, NEIS0102, NEIS0101, NEIS0100 |
| 44 | Nm140 (B: ST351) | Singleton | China (1967) | 26610 | 6,681 | 2094786–2101466 | NEIS2071, NEIS2074, NEIS2075, NEIS2078, NEIS2079 |
| 45 | NmR29026 (C: ST4822) | ST9514 cluster | China (1966) | 86023 | 2,610 | 2101520–2104129 | NEIS2080, NEIS2081, NEIS2082 |
| 46 | 80179 (E: ST178) | CC178 | France (1980) | 34575 | 6,049 | 2117485–2123533 | NEIS2106, NEIS2107, NEIS2108, NEIS2109, NEIS2110, NEIS2112 |
*CC, clonal cluster; ST, sequence type, †Positions are given according to the genome sequence of N. meningitidis strain 053442 (GenBank accession no. NC_010120.1).
1These authors contributed equally to this article.
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