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Volume 27, Number 4—April 2021
Research

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

Mingliang Chen1Comments to Author , Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min ChenComments to Author , and Martin C.J. MaidenComments to Author 
Author affiliations: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (M. Chen, X. Zhang, M. Chen); University of Oxford, Oxford, UK (O.B. Harrison, H.B. Bratcher, Z. Bo, K.A. Jolley, C.M.C. Rodrigues, J.E. Bray, M.C.J. Maiden); Fudan University, Huashan Hospital, Shanghai (Q. Guo)

Main Article

Table 4

Potential donors of horizontal gene transfer events associated with contiguous unique loci in sublineage 44.1 of clonal complex 4821 of Neisseria meningitidis*

Event Donor strain (serogroup: ST) Clonal complex Country (year) PubMLST ID Fragment size, bp Position† NEIS no. unique locus
1 Nm281 (W: ST9486) CC174 China (1977) 19343 2,369 1–2369 NEIS2139, NEIS2140, NEIS2141
2 Nm284 (E: ST9500) Singleton China (1977) 19394 5,188 20775–25962 NEIS0007, NEIS0008
3 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 3,242 27345–30586 NEIS0009
4 Nm420815 (X: ST5586) Singleton China (2008) 85974 5,329 114259–119587 NEIS2052, NEIS2050, NEIS2049
5 Nm252 (B: ST1790) CC41/44 China (1976) 26654 9,627 210681–220307 NEIS1972, NEIS1968, NEIS1967, NEIS1966
6 Nm284 (E: ST9500) Singleton China (1977) 19394 3,886 244692–248577 NEIS1956, NEIS2479, NEIS1954, NEIS1952
7 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 2,180 282425–284604 NEIS1916, NEIS1915, NEIS1914
8 BZ 232 (B: ST38) CC37 The Netherlands (1964) 410 4,349 313176–317524 NEIS0313, NEIS0314
9 Nm289 (C: ST4822) ST9514 cluster China (1977) 19721 5,828 321318–327145 NEIS0320, NEIS0321, NEIS0323
10 Nm259 (B: ST17) Singleton China (1977) 26658 5,885 341967–347851 NEIS0340, NEIS0341, NEIS0342
11 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 1,371 360040–361410 NEIS0355, NEIS0356
12 NmNX21 (B: ST5655) CC8 China (1987) 86022 5,346 365048–370393 NEIS0363
13 NmHE89009 (B: ST5642) Singleton China (1989) 86012 3,549 372802–376350 NEIS0367, NEIS0370
14 NmHE89009 (B: ST5642) Singleton China (1989) 86012 1,076 383868–384943 NEIS0375
15 Nm218 (B: ST10385) Singleton China (1976) 26633 3,652 386208–389859 NEIS0378, NEIS0379
16 W10470 (Y: ST4545) Singleton South Africa (2017) 59858 3,819 410887–414705 NEIS0394, NEIS0395, NEIS0396
17 Nm148 (B: ST32) CC32 China (1967) 26613 1,532 479638–481169 NEIS0458, NEIS0459
18 200067 (B: ST3088) CC35 Bangladesh (2009) 94107 1,602 481200–482801 NEIS0462
19 Nm279 (C: ST9506) ST9514 cluster China (1977) 19400 7,850 573877–581726 NEIS0548, NEIS0550, NEIS0551, NEIS0553, NEIS0555
20 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 3,860 595670–599529 NEIS0567, NEIS0569, NEIS0570
21 P15 (B: ST32) CC32 Norway (1969) 26056 8,751 609318–618068 NEIS0581, NEIS0582, NEIS0583, NEIS0586
22 Nm441102 (B: ST8929) Singleton China (2010) 85986 10,176 632301–642476 NEIS0612, NEIS3022, NEIS0613, NEIS0615, NEIS0617, NEIS0618, NEIS0619, NEIS0620
23 9281 (C: ST8447) CC175 South Africa (2003) 40583 8,269 657348–665616 NEIS0641, NEIS0643, NEIS0644, NEIS0645, NEIS0649
24 Nm279 (C: ST9506) ST9514 cluster China (1977) 19400 6,236 704873–711108 NEIS0685, NEIS0686, NEIS0689, NEIS0690
25 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 4,663 725942–730604 NEIS0711, NEIS0713, NEIS0714
26 11–004 (A: ST5) CC5 China (1984) 82 5,393 739214–744606 NEIS0723, NEIS0724, NEIS0729, NEIS0730
27 61106 (A: ST1) CC1 Niger (1961) 34552 8,069 739627–747695 NEIS0731, NEIS0733
28 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 2,412 1038607–1041018 NEIS1076, NEIS1078
29 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 16,089 1091594–1107682 NEIS1127, NEIS1128, NEIS1129, NEIS1131, NEIS3081, NEIS1132, NEIS1133, NEIS1134, NEIS1137, NEIS1138, NEIS1139
30 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 10,667 1130089–1140755 NEIS1160, NEIS1165, NEIS1168
31 M10 240614 (B: ST9817) singleton UK (2010) 20020 2,533 1198534–1201066 NEIS1229, NEIS1231, NEIS1232, NEIS1233
32 C10695 (cnl: new ST) CC1136 South Africa (2017) 59854 1,852 1491092–1492943 NEIS1479, NEIS1480
33 Nm279 (C: ST9506) ST9514 cluster China (1977) 19400 4,194 1585327–1589520 NEIS1568, NEIS1570, NEIS1571
34 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 4,306 1611638–1615943 NEIS1590, NEIS3123, NEIS1594
35 NM320 (B: ST9513) Singleton China (1977) 19407 1,618 1630175–1631792 NEIS1605
36 NmGZ80028 (A: ST3) CC1 China (1974) 86004 9,784 1644769–1654552 NEIS1618, NEIS1619, NEIS1622, NEIS1624, NEIS1629, NEIS1630
37 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 1,537 1674337–1675873 NEIS1647
38 8044 (C: new ST) Singleton South Africa (2002) 40541 3,081 1675114–1678194 NEIS1649, NEIS1650
39 Nm279 (C: ST9506) ST9514 cluster China (1977) 19400 3,799 1840253–1844051 NEIS1819, NEIS1820, NEIS1822, NEIS1824
40 Nm140 (B: S-351) Singleton China (1967) 26610 2,696 1926888–1929583 NEIS0264, NEIS0261, NEIS0260
41 6183 (C: ST13352) Singleton South Africa (2001) 40534 3,884 1930185–1934068 NEIS0257
42 NmGZ80028 (A: ST3) CC1 China (1974) 86004 2,392 2076119–2078510 NEIS0108, NEIS0107
43 Nm280 (C: ST9514) ST9514 cluster Chna (1977) 52352 6,321 2079333–2085653 NEIS0105, NEIS0104, NEIS3165, NEIS0102, NEIS0101, NEIS0100
44 Nm140 (B: ST351) Singleton China (1967) 26610 6,681 2094786–2101466 NEIS2071, NEIS2074, NEIS2075, NEIS2078, NEIS2079
45 NmR29026 (C: ST4822) ST9514 cluster China (1966) 86023 2,610 2101520–2104129 NEIS2080, NEIS2081, NEIS2082
46 80179 (E: ST178) CC178 France (1980) 34575 6,049 2117485–2123533 NEIS2106, NEIS2107, NEIS2108, NEIS2109, NEIS2110, NEIS2112

*CC, clonal cluster; ST, sequence type, 
†Positions are given according to the genome sequence of N. meningitidis strain 053442 (GenBank accession no. NC_010120.1).

Main Article

1These authors contributed equally to this article.

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