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Volume 27, Number 4—April 2021
Research

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

Mingliang Chen1Comments to Author , Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min ChenComments to Author , and Martin C.J. MaidenComments to Author 
Author affiliations: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (M. Chen, X. Zhang, M. Chen); University of Oxford, Oxford, UK (O.B. Harrison, H.B. Bratcher, Z. Bo, K.A. Jolley, C.M.C. Rodrigues, J.E. Bray, M.C.J. Maiden); Fudan University, Huashan Hospital, Shanghai (Q. Guo)

Main Article

Figure 6

Genomic diversity of clonal complex 4821 Neisseria meningitidis sublineage L44.3 isolates. The numbers underneath the antigen genes and AMR genes are the dominant alleles for that particular gene, and the color blocks for SNPs/1,000 bp were determined using the allele number labeled above each column as the reference allele. The Europe–USA cluster can be further divided into 3 subclusters: subcluster L44.3.1, composed of 3 ST6595 isolates from the United States, all of which contained putatively nonfunctional AniA; L44.3.2, composed of 7 ST3200 isolates from the United Kingdom (n = 6) and Brazil (n = 1); and L44.3.3, composed of 30 isolates with multiple geographic locations. All the isolates from urethral (n = 2) and rectal (n = 4) swabs were assigned to L44.3.2 and L44.3.3, both of which comprised isolates with putatively functional AniA. Scale bar indicates substitutions per site. AMR, antimicrobial resistance; SNP, single-nucleotide polymorphism.

Figure 6. Genomic diversity of clonal complex 4821 Neisseria meningitidis sublineage L44.3 isolates. The numbers underneath the antigen genes and AMR genes are the dominant alleles for that particular gene, and the color blocks for SNPs/1,000 bp were determined using the allele number labeled above each column as the reference allele. The Europe–USA cluster can be further divided into 3 subclusters: subcluster L44.3.1, composed of 3 ST6595 isolates from the United States, all of which contained putatively nonfunctional AniA; L44.3.2, composed of 7 ST3200 isolates from the United Kingdom (n = 6) and Brazil (n = 1); and L44.3.3, composed of 30 isolates with multiple geographic locations. All the isolates from urethral (n = 2) and rectal (n = 4) swabs were assigned to L44.3.2 and L44.3.3, both of which comprised isolates with putatively functional AniA. Scale bar indicates substitutions per site. AMR, antimicrobial resistance; SNP, single-nucleotide polymorphism.

Main Article

1These authors contributed equally to this article.

Page created: March 02, 2021
Page updated: March 18, 2021
Page reviewed: March 18, 2021
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