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Volume 27, Number 5—May 2021
Research

Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020

Philip Eisermann1, Dennis Rubbenstroth1, Daniel Cadar, Corinna Thomé-Bolduan, Petra Eggert, Alexander Schlaphof, Frank Leypoldt, Martin Stangel, Thorsten Fortwängler, Florian Hoffmann, Andreas Osterman, Sabine Zange, Hans-Helmut Niller, Klemens Angstwurm, Kirsten Pörtner, Christina Frank, Hendrik Wilking, Martin Beer, Jonas Schmidt-Chanasit, and Dennis TappeComments to Author 
Author affiliations: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany (P. Eisermann, D. Cadar, C. Thomé-Bolduan, P. Eggert, A. Schlaphof, J. Schmidt-Chanasit, D. Tappe); Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany (D. Rubbenstroth, M. Beer); University Medical Center Schleswig-Holstein, Kiel, Germany (F. Leypoldt); Medizinische Hochschule Hannover, Hannover, Germany (M. Stangel); Donau-Isar-Klinikum Deggendorf, Deggendorf, Germany (T. Fortwängler); Ludwig-Maximilians-University, Munich, Germany (F. Hoffmann); Max von Pettenkofer Institute, Munich (A. Osterman); German Center for Infection Research, Munich (A. Osterman); Bundeswehr Institute of Microbiology, Munich (S. Zange); Regensburg University Hospital, Regensburg, Germany (H.-H. Niller, K. Angstwurm); Postgraduate Training for Applied Epidemiology, Berlin, Germany (K. Pörtner); European Centre for Disease Prevention and Control, Stockholm, Sweden (K. Pörtner); Robert Koch Institute, Berlin (K. Pörtner, C. Frank, H. Wilking)

Main Article

Table 2

Line blot results for 4 case-patients who had bornavirus encephalitis, Germany, 2018–2020*

Case no. Virus Serum
 Cerebrospinal fluid
IFAT VSBV-1 P BoDV-1 P IFAT VSBV-1 P BoDV-1 P
1 VSBV-1 655,360 62 54 20,480 49 32
2 BoDV-1 640 9 30 80 2 14
3 BoDV-1 2,560 4 17 160 2 2
4 BoDV-1 2,560 2 1 160 1 0

*Cutoff value is 16 arbitrary units per antigen; positive results are indicated in bold. Results of antibody testing against heterologous antigens are indicated in italics. BoDV-1, Borna disease virus 1; IFAT, immunofluorescence antibody test; P, phosphoprotein; VSBV-1, variegated squirrel bornavirus 1.

Main Article

1These authors contributed equally to this article.

Page created: February 08, 2021
Page updated: April 20, 2021
Page reviewed: April 20, 2021
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