Volume 27, Number 6—June 2021
Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children
|Time period||Estimated hospitalizations
||Total hospitalizations averted
|Observed, with vaccination
||Expected without vaccination
|Pre-PCV era: 1997–1999||NA||NA||339,474||525,675||NA||NA|
|PCV7 era: 2000–2009†||959,543||1,336,673||597,479||1,822,591||222,611||490,043‡|
|PCV13 era: 2010–2019§||382,182
*PCV7 was approved for use in the United States in 2000; PCV13 was approved for use in the United States in 2010. NA, not applicable; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent PCV; PCV13, 13-valent PCV. †Averted hospitalizations during PCV7 era are shown as the difference within the same study with minimum based on Simonson et. al. (24) and maximum based on Grijalva et al (29) (Appendix Table 14). ‡Grijalva et al (29) reported a change in hospitalization rate; as a result, no observed and expected values were generated. §Values based on calculations using a single data point.
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