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Volume 27, Number 6—June 2021

Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children

Matt WassermanComments to Author , Ruth Chapman, Rotem Lapidot, Kelly Sutton, Desmond Dillon-Murphy, Shreeya Patel, Erica Chilson, Vincenza Snow, Raymond Farkouh, and Stephen Pelton
Author affiliations: Pfizer Inc., New York, New York, USA (M. Wasserman, E. Chilson, V. Snow, R. Farkouh); Evidera Market Access Ltd, London, UK (R. Chapman, K. Sutton, D. Dillon-Murphy, S. Patel); Boston University School of Medicine, Boston, Massachusetts, USA (R. Lapidot, S. Pelton)

Main Article

Table 4

Estimated total hospitalized cases of pneumonia averted by PCVs, United States, 1997–2019*

Time period Estimated hospitalizations
Total hospitalizations averted
Observed, with vaccination

Expected without vaccination
Minimum Maximum Minimum Maximum Minimum Maximum
Pre-PCV era: 1997–1999 NA NA 339,474 525,675 NA NA
PCV7 era: 2000–2009† 959,543 1,336,673 597,479 1,822,591 222,611 490,043‡
PCV13 era: 2010–2019§ 382,182

*PCV7 was approved for use in the United States in 2000; PCV13 was approved for use in the United States in 2010. NA, not applicable; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent PCV; PCV13, 13-valent PCV.
†Averted hospitalizations during PCV7 era are shown as the difference within the same study with minimum based on Simonson et. al. (24) and maximum based on Grijalva et al (29) (Appendix Table 14).
‡Grijalva et al (29) reported a change in hospitalization rate; as a result, no observed and expected values were generated.
§Values based on calculations using a single data point.

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Page updated: May 18, 2021
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