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Volume 27, Number 6—June 2021
Research

Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children

Matt WassermanComments to Author , Ruth Chapman, Rotem Lapidot, Kelly Sutton, Desmond Dillon-Murphy, Shreeya Patel, Erica Chilson, Vincenza Snow, Raymond Farkouh, and Stephen Pelton
Author affiliations: Pfizer Inc., New York, New York, USA (M. Wasserman, E. Chilson, V. Snow, R. Farkouh); Evidera Market Access Ltd, London, UK (R. Chapman, K. Sutton, D. Dillon-Murphy, S. Patel); Boston University School of Medicine, Boston, Massachusetts, USA (R. Lapidot, S. Pelton)

Main Article

Table 4

Estimated total hospitalized cases of pneumonia averted by PCVs, United States, 1997–2019*

Time period Estimated hospitalizations
 Total hospitalizations averted
Observed, with vaccination
Expected without vaccination
Minimum Maximum Minimum Maximum Minimum Maximum
Pre-PCV era: 1997–1999 NA NA 339,474 525,675 NA NA
PCV7 era: 2000–2009† 959,543 1,336,673 597,479 1,822,591 222,611 490,043‡
PCV13 era: 2010–2019§ 382,182
 598,484
 216,303

*PCV7 was approved for use in the United States in 2000; PCV13 was approved for use in the United States in 2010. NA, not applicable; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent PCV; PCV13, 13-valent PCV.
†Averted hospitalizations during PCV7 era are shown as the difference within the same study with minimum based on Simonson et. al. (24) and maximum based on Grijalva et al (29) (Appendix Table 14).
‡Grijalva et al (29) reported a change in hospitalization rate; as a result, no observed and expected values were generated.
§Values based on calculations using a single data point.

Main Article

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Page created: April 15, 2021
Page updated: May 18, 2021
Page reviewed: May 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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