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Volume 27, Number 6—June 2021
Research

Twenty-Year Public Health Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in US Children

Matt WassermanComments to Author , Ruth Chapman, Rotem Lapidot, Kelly Sutton, Desmond Dillon-Murphy, Shreeya Patel, Erica Chilson, Vincenza Snow, Raymond Farkouh, and Stephen Pelton
Author affiliations: Pfizer Inc., New York, New York, USA (M. Wasserman, E. Chilson, V. Snow, R. Farkouh); Evidera Market Access Ltd, London, UK (R. Chapman, K. Sutton, D. Dillon-Murphy, S. Patel); Boston University School of Medicine, Boston, Massachusetts, USA (R. Lapidot, S. Pelton)

Main Article

Table 1

Invasive pneumococcal disease cases and deaths averted by pneumococcal conjugate vaccines, United States, 1997–2019*

Year No. observed, by age, y
 No. expected, by age, y
 No. averted
<1 1 2–4 Overall <1 1 2–4 Overall Annual Cumulative
No. cases
1997 5,360 6,712 3,635 15,707 5,360 6,712 3,635 15,707 NA NA
1998 6,220 7,630 4,286 18,136 6,220 7,630 4,286 18,136 NA NA
1999 6,176 7,772 3,837 17,785 6,176 7,772 3,837 17,785 NA NA
2000 5,699 6,139 3,469 15,306 6,053 7,428 3,883 17,364 2,057 2,057
2001 2,099 2,645 3,143 7,887 6,299 7,539 3,852 17,689 9,802 11,860
2002 1,521 1,261 1,813 4,596 6,202 7,830 3,866 17,899 13,304 25,164
2003 1,642 1,405 1,530 4,577 6,241 7,696 3,936 17,874 13,296 38,460
2004 1,485 1,253 1,454 4,192 6,301 7,730 3,983 18,013 13,821 52,281
2005 1,450 1,419 1,467 4,336 6,286 7,796 4,019 18,101 13,765 66,046
2006 1,366 1,458 1,395 4,219 6,344 7,767 4,019 18,130 13,911 79,956
2007 1,680 1,296 1,560 4,537 6,511 7,826 4,036 18,372 13,835 93,792
2008 1,517 1,284 1,420 4,221 6,487 8,018 4,057 18,562 14,341 108,133
2009 1,485 1,309 1,654 4,449 6,284 7,975 4,099 18,358 13,910 122,043
2010 1,352 1,051 1,611 4,014 6,204 7,726 4,144 18,074 14,060 136,103
2011 832 670 1,012 2,515 6,221 7,755 4,109 18,085 15,571 151,674
2012 616 541 712 1,870 6,163 7,777 4,068 18,009 16,139 167,813
2013 578 595 814 1,988 6,171 7,709 4,036 17,916 15,928 183,741
2014 629 407 754 1,790 6,208 7,721 4,033 17,963 16,173 199,914
2015 733 513 610 1,856 6,253 7,769 4,031 18,053 16,198 216,112
2016 526 212 167 906 6,208 7,828 4,032 18,068 17,163 233,275
2017 452 314 625 1,391 6,112 7,770 4,052 17,934 16,544 249,818
2018 446 309 627 1,382 6,040 7,651 4,061 17,752 16,370 266,188
2019
 446
 309
 627
 1,382
6,040
 7,651
 4,061
 17,752
16,370
 282,558
No. deaths
1997 151 34 17 202 151 34 17 202 NA NA
1998 78 47 NA 126 78 47 NA 126 NA NA
1999 29 45 60 134 29 45 60 134 NA NA
2000 130 113 57 301 138 137 64 340 39 39
2001 22 46 57 125 103 66 36 204 79 118
2002 31 NA 32 62 101 68 36 205 143 261
2003 42 21 21 85 102 67 37 206 121 382
2004 39 48 20 107 103 67 37 207 101 483
2005 38 9 38 85 103 68 37 208 123 605
2006 29 9 47 85 104 68 37 209 124 729
2007 37 9 9 56 106 68 37 212 156 885
2008 37 NA 18 55 106 70 38 214 158 1,043
2009 36 9 9 54 103 70 38 210 156 1,199
2010 10 9 9 28 101 67 38 207 179 1,378
2011 38 19 28 85 102 68 38 207 123 1,501
2012 9 9 NA 19 101 68 38 206 187 1,688
2013 9 9 38 57 101 67 37 205 149 1,837
2014 19 NA 9 28 101 67 37 206 178 2,014
2015 10 9 19 38 102 68 37 207 170 2,184
2016 18 4 12 35 101 68 37 207 172 2,356
2017 28 19 38 85 100 68 38 205 120 2,476
2018 16 7 28 51 99 67 38 203 152 2,628
2019 16 7 28 51 99 67 38 203 152 2,780

*Values are rounded to the nearest whole numbers. NA, not applicable.

Main Article

Page created: April 15, 2021
Page updated: May 18, 2021
Page reviewed: May 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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