Volume 27, Number 6—June 2021
CME ACTIVITY - Research
HIV Infection as Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012–2017
Table 3
Random-effects multivariable logistic regression analysis of the effect of HIV on in-hospital death by sentinel site, simultaneously adjusted for potential confounders, among 907 persons with candidemia, South Africa, 2012–2017*
Variable | Summary aOR for death (95% CI) | Wald p value |
---|---|---|
HIV status | ||
Seronegative | Referent | |
Seropositive |
1.89 (1.38–2.60) |
<0.001 |
Age group, y | ||
<18 | Referent | |
18–44 | 2.55 (1.66–3.93) | <0.001 |
45–64 | 3.48 (2.21–5.49) | <0.001 |
>65 |
6.47 (3.61–11.61) |
<0.001 |
Sex | ||
F | Referent | |
M |
1.27 (0.95–1.70) |
0.11 |
Year | ||
2012 | Referent | |
2013 | 1.26 (0.72–2.19) | 0.42 |
2014 | 1.34 (0.67–2.68) | 0.40 |
2015 | 1.17 (0.58–2.33) | 0.66 |
2016 | 1.08 (0.63–1.86) | 0.77 |
2017 |
1.53 (0.90–2.61) |
0.12 |
ICU admission | ||
No | Referent | |
Yes |
1.70 (1.23–2.36) |
0.001 |
Receipt of systemic antifungal treatment | ||
No | Referent | |
Yes |
0.35 (0.25–0.48) |
<0.001 |
Candida species | ||
C. albicans | Referent | |
Other Candida spp. | 0.66 (0.49–0.89) | 0.006 |
*aOR, adjusted odds ratio; ICU, intensive care unit. Intra-cluster correlation coefficient = 0.03; likelihood ratio test for ρ = 0; p value = 0.003.
1Members of GERMS-SA are listed at the end of this article.