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Volume 27, Number 6—June 2021
CME ACTIVITY - Research

HIV Infection as Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012–2017

Nelesh P. GovenderComments to Author , Jim Todd, Jeremy Nel, Mervyn Mer, Alan Karstaedt, Cheryl Cohen, and for GERMS-SA1
Author affiliations: University of Cape Town, Cape Town, South Africa (N.P. Govender); University of the Witwatersrand, Johannesburg (N.P. Govender, J. Nel, M. Mer, A. Karstaedt, C. Cohen); National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, South Africa (N.P. Govender, C. Cohen); London School of Hygiene and Tropical Medicine, London, UK (J. Todd)

Main Article

Table 3

Random-effects multivariable logistic regression analysis of the effect of HIV on in-hospital death by sentinel site, simultaneously adjusted for potential confounders, among 907 persons with candidemia, South Africa, 2012–2017*

Variable Summary aOR for death (95% CI) Wald p value
HIV status
Seronegative Referent
Seropositive
 1.89 (1.38–2.60)
 <0.001
Age group, y
<18 Referent
18–44 2.55 (1.66–3.93) <0.001
45–64 3.48 (2.21–5.49) <0.001
>65
 6.47 (3.61–11.61)
 <0.001
Sex
F Referent
M
 1.27 (0.95–1.70)
 0.11
Year
2012 Referent
2013 1.26 (0.72–2.19) 0.42
2014 1.34 (0.67–2.68) 0.40
2015 1.17 (0.58–2.33) 0.66
2016 1.08 (0.63–1.86) 0.77
2017
 1.53 (0.90–2.61)
 0.12
ICU admission
No Referent
Yes
 1.70 (1.23–2.36)
 0.001
Receipt of systemic antifungal treatment
No Referent
Yes
 0.35 (0.25–0.48)
 <0.001
Candida species
C. albicans Referent
Other Candida spp. 0.66 (0.49–0.89) 0.006

*aOR, adjusted odds ratio; ICU, intensive care unit. Intra-cluster correlation coefficient = 0.03; likelihood ratio test for ρ = 0; p value = 0.003.

Main Article

1Members of GERMS-SA are listed at the end of this article.

Page created: April 13, 2021
Page updated: May 19, 2021
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