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Volume 27, Number 7—July 2021
Research

Plasmodium falciparum kelch 13 Mutations, 9 Countries in Africa, 2014–2018

Sarah E. Schmedes1, Dhruviben Patel1, Simran Dhal, Julia Kelley, Samaly S. Svigel, Pedro Rafael Dimbu, Adicatou-Laï Adeothy, Gauthier Mesia Kahunu, Papy Mandoko Nkoli, Abdoul Habib Beavogui, Simon Kariuki, Don P. Mathanga, Ousmane Koita, Deus Ishengoma, Ally Mohamad, Moonga Hawela, Leah F. Moriarty, Aaron M. Samuels, Julie Gutman, Mateusz M. Plucinski, Venkatachalam Udhayakumar, Zhiyong Zhou, Naomi W. Lucchi, Meera Venkatesan, Eric S. Halsey, and Eldin TalundzicComments to Author 
Author affiliations: Association of Public Health Laboratories, Silver Spring, Maryland, USA (S.E. Schmedes); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.E. Schmedes, D. Patel, S.S. Svigel, A.M. Samuels, J. Gutman, M.M. Plucinski, V. Udhayakumar, Z. Zhou, N.W. Lucchi, E. Talundzic); Williams Consulting LLC, Baltimore, Maryland, USA (D. Patel); The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta (S. Dahl); CDC Foundation, Atlanta (J. Kelley); National Malaria Control Program, Ministry of Health, Luanda, Angola (P.R. Dimbu); National Malaria Control Program, Ministry of Health, Porto-Novo, Benin (A.-L. Adeothy); University of Kinshasa, Kinshasa, Democratic Republic of the Congo (G.M. Kahunu); National Institute of Biomedical Research, Kinshasa (P.M. Nkoli); Maferinyah Rural Health Research Center, Mafèrinyah, Guinea (A.H. Beavogui); Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya (S. Kariuki); University of Malawi College of Medicine, Blantyre, Malawi (D.P. Mathanga); University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali (O. Koita); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (D. Ishengoma); National Institute for Medical Research, Tanga Research Centre, Dar es Salaam, Tanzania (D. Ishengoma, A. Mohamad); Monash University Faculty of Pharmaceutical Sciences, Melbourne, Australia (D. Ishengoma); National Malaria Elimination Centre, Lusaka, Zambia (M. Hawela); US President’s Malaria Initiative, Centers for Disease Control and Prevention, Atlanta (L.F. Moriarty, M.M. Plucinski, E.S. Halsey); US President’s Malaria Initiative, US Agency for International Development, Washington, DC, USA (M. Venkatesan)

Main Article

Table 3

Summary of Pfk13 gene mutations detected in Plasmodium falciparum pretreatment and DF samples, 9 countries in Africa, 2014–2018*

 No. samples pretreatment (DF)
Country (year) Total with sequencing attempted Poor quality or no amplification Successfully sequenced Wild-type samples
pretreatment 		Other nonsynonymous mutations Synonymous mutations
Angola (2015) 379 (0) 77 (0) 302 (0) 291 (0) 5 (0) 6 (0)
Angola (2017) 38 (38) 0 (2) 38 (36) 37 (36) 1 (0) 0 (0)
Benin (2017) 175 (19) 20 (1) 155 (18) 151 (18) 1 (0) 3 (0)
DRC (2017–2018) 317 (316) 13 (34) 304 (282) 295 (269) 1 (2) 8 (11)
Guinea (2016) 409 (23) 20 (1) 389 (22) 380 (22) 1 (0) 8 (0)
Kenya (2016–2017) 325 (92) 7 (4) 318 (88) 302 (85) 8 (2) 8 (1)
Malawi (2014) 8 (19) 1 (5) 7 (14) 7 (14) 0 (0) 0 (0)
Mali (2015–2016) 320 (90) 68 (48) 252 (42) 244 (39) 1 (0) 7 (3)
Tanzania (2016) 345 (72) 20 (12) 325 (60) 306 (57) 6 (0) 13 (3)
Zambia (2016)
 263 (0)
 50 (0)
 213 (0)
 200 (0)
 1 (0)
 12 (0)
Total 2,579 (669) 276 (107) 2,303 (562) 2,213 (540) 25 (4) 65 (18)

*DF, day of failure; DRC, Democratic Republic of the Congo; Pfk13, Plasmodium falciparum kelch 13.

Main Article

1These authors contributed equally to this article.

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Page updated: June 16, 2021
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