Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 7—July 2021
CME ACTIVITY - Research

Non–C. difficile Clostridioides Bacteremia in Intensive Care Patients, France

Guillaume MorelComments to Author , Guillaume Mulier, Etienne Ghrenassia, Moustafa Abdel Nabey, Yacine Tandjaoui, Achille Kouatchet, Laura Platon, Frédéric Pène, Anne-Sophie Moreau, Amelie Seguin, Damien Contou, Romain Sonneville, David Rousset, Muriel Picard, Guillaume Dumas, Djamel Mokart, Bruno Megarbane, Guillaume Voiriot, Isabelle Oddou, Elie Azoulay, Lucie Biard, and Lara Zafrani
Author affiliations: Hautepierre Hospital—University Medical Center, Strasbourg, France (G. Morel); Hospital Saint Louis, APHP, Paris, France (G. Morel, G. Mulier, E. Ghrenassia, M.A. Nabey, E. Azoulay, L. Biard, L. Zafrani); Hospital Avicenne, Bobigny, France (Y. Tandjaoui); Teaching Hospital, Angers, France (A. Kouatchet); Lapeyronie University Hospital, Montpellier, France (L. Platon); Hospital Cochin, APHP, Paris (F. Pène); Salengro Hospital, Lille, France (A.-S. Moreau); University Hospital, Nantes, France (A. Seguin); Victor Dupouy Hospital, Argenteuil, France (D. Contou); Hospital Bichat, APHP, Paris (R. Sonneville); University Teaching Hospital, Toulouse, France (D. Rousset),; Institut Universitaire du Cancer—Oncopole, Toulouse (M. Picard); Hospital Saint Antoine, APHP, Paris (G. Dumas); Paoli-Calmettes Institute, Marseille, France (D. Mokart); Hospital Lariboisiere, APHP, Paris (B. Megarbane); Hospital Tenon, APHP, Paris (G. Voiriot); University Medical Center, Strasbourg (I. Oddou); INSERM U976, Paris (L. Zafrani)

Main Article

Table 2

Clinical and biologic characteristics of patients with Closteridiodes bacteremia, France*

Characteristic All patients, n = 135
 Survived, n = 65
 Died in ICU, n = 70
No. Result No. Result No. Result
Temperature
 75
 37 (36–39)
30
 38.5 (37.3–39)
45
 37 (35.6–38.7)
Clinical manifestations associated with bacteremia at ICU admission
Septic shock 115 85% 49 75% 66 94%
Digestive symptoms 84 62% 42 65% 42 60%
Acute respiratory failure 41 30% 15 23% 26 37%
Coma 38 28% 6 9% 32 46%
Cardiac arrest 26 19% 2 3% 24 34%
Myonecrosis
 21
 16%
11
 17%
10
 14%
Prognostic scores at ICU admission
Charlson score 135 5 (3–6) 65 5 (2–7) 70 4.5 (3–6)
SAPS2 score 106 63 (44–88) 47 45 (33–57) 59 82 (63–97)
SOFA score
 105
 10 (7–14)
47
 8 (5–10)
58
 12 (9–15)
Organ support in ICU
Vasopressors, n = 132 108 82% 42 66% 66 97%
Mechanical ventilation, n = 133 105 79% 41 63% 64 94%
Renal-replacement therapy, n = 131
 44
 34%
17
 26%
27
 41%
Biologic parameters at ICU admission
Leukocytes, × 109/L 97 9.5 (2.8–17.8) 49 9.5 (6.1–20.2) 48 9.3 (1.6–16.0)
Platelets, × 109/L 93 141 (76–214) 45 143 (73–217) 48 138 (84–206)
Hemoglobin, g/dL 92 10.3 (7.8–12.2) 45 10.2 (8.8–12.2) 47 10.3 (7.0–11.9)
Hemolysis, n = 130
 22
 17%
6
 9%
16
 24%
Acute renal failure, n = 107
KDIGO classification 1 14 13% 10 20% 4 7%
KDIGO classification 2 34 32% 19 38% 15 26%
KDIGO classification 3
 59
 55%
21
 42%
38
 67%
Other
Aspartate aminotransferase, UI/L 80 92 (41–269) 38 71 (41–172) 42 134 (44–346)
Alanine aminotransferase, UI/L 81 54 (25–142) 39 47 (21–125) 42 69 (27–152)
Bilirubin, µmol/L 69 22 (10–45) 34 27 (10.3–52.3) 35 19.5 (10.5–35.7)
Lactatemia, mmol/L 93 5.3 (2.3–8.8) 40 3.2 (1.5–5.2) 53 8 (4.9–12)
pH 93 7.29 (7.13–7.4) 40 7.38 (7.32–7.43) 53 7.18 (7.05–7.31)

*Results are given as percentages or median (interquartile range). ICU, intensive care unit; KDIGO, Kidney Disease: Improving Global Outcomes (https://kdigo.org); SAPS2, simplified acute physiology score (SAPS2); SOFA, sequential organ failure assessment.

Main Article

Page created: May 27, 2021
Page updated: June 18, 2021
Page reviewed: June 18, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external