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Volume 27, Number 9—September 2021
Research

Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019

Ricardo Ariel Gianecini, Tomas Poklepovich, Daniel Golparian, Noelia Cuenca, Ezequiel Tuduri, Magnus Unemo, Josefina Campos, Patricia GalarzaComments to Author , and Gonococcal Antimicrobial Susceptibility Surveillance Programme—Argentina1
Author affiliations: Instituto Nacional de Enfermedades Infecciosas—Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina (R.A. Gianecini, T. Poklepovich, N. Cuenca, E. Tuduri, J. Campos, P. Galarza); World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Örebro University, Örebro, Sweden (D. Golparian, M. Unemo)

Main Article

Table 1

Characteristics of 96 azithromycin-resistant Neisseria gonorrhoeae isolates, Argentina, January 2005–November 2019*

Characteristics
 MICs for azithromycin, μg/mL
2–4
 8–16
 >256
Total 78 13 5
Province
 Buenos Aires, CABA, Córdoba, Neuquén, La Pampa, Río Negro, Santa Fe
 CABA, Córdoba
 Buenos Aires, CABA, Córdoba
Resistance determinants
23S rRNA (no. mutated alleles; 
total no. isolates) C2611T (4; 58); C2611T (1; 1) C2611T (4; 12); C2611T (3; 1) A2059G (4; 5)
MtrR protein (no. isolates) A-deletion (12)†; N. meningitidis–like (14); G45D (41); mtr120 (0)‡ A-deletion (6); G45D (3); mtr120 (0) N. meningitidis–like (4); G45D (1); mtr120 (0)
Mosaic mtr locus (no. isolates)
 mtrC (14); mtrD (14); mtrE (13)
 mtrC (0); mtrD (0); mtrE (0)
 mtrC (4); mtrD (4); mtrE (4)
ST
N. gonorrhoeae multiantigen 
sequence typing (no. isolates) ST470 (23); ST20102 (7); ST696 (4); ST12302 (4); ST11062 (3); other STs (37) ST18761 (3); ST20104 (3); singleton STs (7) ST3935 (2); ST20106 (2); ST696 (1)
Multilocus sequence typing (no. 
isolates) ST1580 (39); ST1584 (10); ST9363 (10); ST1901 (8); other STs (11) ST1901 (6); ST1580 (3); ST13844 (3); ST13594 (1) ST9363 (4); ST1580 (1)
N. gonorrhoeae sequence typing for 
antimicrobial resistance (no. isolates) ST1038 (30); ST179 (10); ST168 (5); ST3200 (4); other STs (29) ST27 (4); ST2728 (3); ST1038 (2); singleton STs (4) ST1993 (2); ST2906 (1); ST3194 (1); ST3199 (1)

*CABA, Ciudad Autónoma de Buenos Aires; ST, sequence type. †Deletion of A in 13-bp inverted repeat sequence of the mtrR gene. ‡C-to-T transition mutation 120 bp upstream of the mtrC start codon.

Main Article

1Members of this group are listed at the end of the article.

Page created: July 01, 2021
Page updated: August 17, 2021
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