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Volume 28, Supplement—December 2022
SUPPLEMENT ISSUE
Synopsis

Leveraging HIV Program and Civil Society to Accelerate COVID-19 Vaccine Uptake, Zambia

Patricia Bobo, Jonas Z. HinesComments to Author , Roma Chilengi, Andrew F. Auld, Simon G. Agolory, Andrew Silumesii, and John Nkengasong
Author affiliations: Ministry of Health, Lusaka, Zambia (P. Bobo, A. Silumesii); US Centers for Disease Control and Prevention, Lusaka (J.Z. Hines, S.G. Agolory); Republic of Zambia State House, Lusaka (R. Chilengi); The Global Fund, Geneva, Switzerland (A.F. Auld); Africa Center for Disease Control, Addis Ababa, Ethiopia (J. Nkengasong)

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Abstract

To accelerate COVID-19 vaccination delivery, Zambia integrated COVID-19 vaccination into HIV treatment centers and used World AIDS Day 2021 to launch a national vaccination campaign. This campaign was associated with significantly increased vaccinations, demonstrating that HIV programs can be leveraged to increase COVID-19 vaccine uptake.

COVID-19 vaccine scale-up in Africa, the continent with the lowest vaccine coverage, is a current regional and global priority. As of May 1, 2022, only 17% of persons in Africa had been fully vaccinated (1). Initial vaccination campaigns in Africa were hampered by lower-than-forecasted vaccine donations (2). However, through efforts from multiple stakeholders, the vaccine supply to countries in Africa increased in the latter half of 2021. However, with increasing vaccine availability, new challenges became apparent, including the difficulty for under-resourced health systems with relatively low healthcare worker–to–population ratios to implement COVID-19 vaccination services, as well as difficulties reaching populations unaccustomed to adult immunization programs and vaccine misperceptions and misinformation. Facing these challenges, in August 2021, the government of Zambia worked with stakeholders to leverage its national HIV program (which has been supported by >$5 billion in funding in the previous 20 years) to enhance its COVID-19 vaccine campaign.

Zambia integrated COVID-19 vaccination into its existing HIV treatment centers with the goal of offering patients and family members vaccination services, thereby rapidly expanding static vaccination site numbers in the country. Successful strategies for engaging HIV treatment centers included using existing human resources by adequately preparing HIV healthcare workers to offer vaccination and encouraging them to get vaccinated themselves, developing targeted promotional materials for persons living with HIV who are at increased risk for severe illness (3), and rapidly adapting and implementing similar models across the country. After this preparatory work, Zambia used the annual World AIDS Day event to launch its December Campaign to help reach African Union targets (4), focusing on engaging civil society leaders to endorse vaccination and using a mixed service delivery model that added community-delivered vaccination based on successful community HIV programs to existing static service delivery (Table). Some strategies were adapted from Zambia’s robust childhood vaccination program (5).

To evaluate whether the December Campaign accelerated COVID-19 vaccination in Zambia, we conducted time-series analyses by using publicly available data (Appendix) (1). All participants entered in the Our World in Data dataset by February 21, 2022, for Zambia and 55 African Union member states were eligible for the analysis. We conducted 3 statistical analyses. First, in a single-group interrupted time-series analysis in Zambia only, we compared the number of persons reaching full vaccination status per day before the December 1, 2021, campaign start versus after the campaign start. Second, in a multigroup interrupted time-series analysis, we assessed whether Zambia’s acceleration in COVID-19 vaccination coverage (i.e., acceleration in the percentage of total population reaching full vaccination status per day) after the December Campaign intervention was statistically superior to 2 control groups: 2 neighboring countries with similar pre-intervention vaccination coverage trajectories and similar vaccine availability, and the average for all 55 Africa Union member states. Third, we implemented 2 sensitivity analyses for each of the above 2 analytic approaches by varying the approach to managing missing data (i.e., most recent value carried forward approach vs. interpolation approach) and comparing varied time periods for the analysis to determine the duration of December Campaign effect.

Figure

Time series of COVID-19 vaccination in Zambia, April 2021 to February 2022. A) Before and after the December Campaign. B) Compared with 2 neighboring countries with similar pre-intervention vaccination coverage trajectories and similar vaccine availability. C) Compared with the average for all 55 Africa Union member states. Prais-Winsten and Cochrane-Orcutt regression, lag(1). Vertical dashed line indicates start of Joint HIV Awareness and COVID-19 Vaccination Drive, December 1, 2021.

Figure. Time series of COVID-19 vaccination in Zambia, April 2021 to February 2022. A) Before and after the December Campaign. B) Compared with 2 neighboring countries with similar pre-intervention vaccination coverage...

During December 2021, a total of 585,677 persons in Zambia were reached for vaccination, compared with approximately 1,071,682 million during April–November 2021. Daily COVID-19 vaccinations increased from 3,713/day before December 2021 to 17,783/day after December 1, 2021 (p<0.001) (Figure, panel A; Appendix Table 3).

Compared with the average for 2 neighboring countries with similar vaccination trends before December and vaccine availability, Zambia accelerated its population COVID-19 vaccine coverage rate by an additional 2.73%/month (p<0.001) (Figure, panel B; Appendix Table 4). Compared with Africa as a whole, Zambia vaccine coverage accelerated by 1.87%/month (p<0.001) (Figure, panel C; Appendix Table 5). This accelerated vaccination in Zambia was robust to the sensitivity analysis for which we used an interpolation approach to missing data instead of the approach carrying forward the most recent available data point (Appendix Tables 3, 6). In addition, the average post-December daily vaccination rate dropped only slightly, and the average post-December percentage gain per day in a fully vaccinated population remained relatively stable, indicating a sustained effect for nearly 3 months after the December Campaign launch. If current trends were sustained, Zambia could reach its targeted 70% eligible population coverage in November 2023, ahead of other countries in Africa (August 2024) (Appendix Table 7).

For Africa to reach the 2022 Africa Union targets and adequately protect the continent from subsequent COVID-19 waves, substantially accelerated COVID-19 vaccination delivery is needed (4). Moreover, rapidly reaching high vaccination coverage in Africa can help reduce the risk for emergence of new variants that can rapidly spread globally (6,7). These data suggest that strong government leadership can leverage a robust HIV program, civil society, and integrated HIV donor support from the US President’s Emergency Plan for AIDS Relief and others to rapidly increase COVID-19 vaccine uptake. Zambia`s example could hasten similar adaptations in other Africa countries.

Dr. Bobo is a pediatrician and director of the Child Health and Nutrition Unit at the Zambia Ministry of Health, who oversees COVID-19 vaccination efforts in Zambia.

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Acknowledgments

We thank Francis D. Mwansa, Constance Sakala, Paul Chishimba, David Ngula, Sam Phiri, Liswaniso Liswaniso, Patrick Lungu, Mushota Kabaso, Lackson Kasonka Ray W. Shiraishi,, Kayt Erdahl, Daniel Sinclair, Penelope Masumbu Kalesha, and Monjur Hossain for their work as part of the Zambia COVID-19 Vaccine Scale-Up Committee.

This work has been supported by the Zambia Ministry of Health and the US President’s Emergency Plan for AIDS Relief through Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the funding agencies.

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References

  1. Ritchie  H, Mathieu  E, Rodés-Guirao  L, Appel  C, Giattino  C, Ortiz-Ospina  E, et al. Coronavirus pandemic (COVID-19) [cited 2022 Feb 22]. https://ourworldindata.org/coronavirus
  2. World Health Organization Regional Office for Africa. Africa faces 470 million COVID-19 vaccine shortfall in 2021 [cited 2022 Jan 11]. https://www.afro.who.int/news/africa-faces-470-million-covid-19-vaccine-shortfall-2021
  3. World Health Organization). Clinical features and prognostic factors of COVID-19 in people living with HIV hospitalized with suspected or confirmed SARS-CoV-2 infection [cited 2022 Feb 22]. https://apps.who.int/iris/bitstream/handle/10665/342697/WHO-2019-nCoV-Clinical-HIV-2021.1-eng.pdf
  4. World Health Organization (WHO). Leaders make urgent call to accelerate vaccination globally and in Africa [cited 2022 Feb 22]. https://www.who.int/news/item/14-09-2021-leaders-make-urgent-call-to-accelerate-vaccination-globally-and-in-africa
  5. Micek  K, Hester  KA, Chanda  C, Darwar  R, Dounebaine  B, Ellis  AS, et al.; Vaccine Exemplars Research Consortium. Critical success factors for routine immunization performance: A case study of Zambia 2000 to 2018. Vaccine X. 2022;11:100166. DOIPubMedGoogle Scholar
  6. Nkengasong  J. There will be another variant. Here’s what the world can do now [cited 2022 Feb 22]. https://www.nytimes.com/2022/01/20/opinion/covid-variant-omicron.html
  7. Corey  L, Corbett-Detig  R, Beyrer  C. Expanding efforts and support to respond to the HIV and COVID-19 intersecting pandemics. JAMA. 2022;327:12278. DOIPubMedGoogle Scholar

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Cite This Article

DOI: 10.3201/eid2813.220743

Original Publication Date: October 11, 2022

Table of Contents – Volume 28, Supplement—December 2022

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Jonas Hines, US Centers for Disease Control and Prevention, 351 Independence Ave, Woodlands, Lusaka, Zambia

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Page created: October 11, 2022
Page updated: October 17, 2022
Page reviewed: October 17, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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