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Volume 28, Number 2—February 2022

West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States

Raymond A. SotoComments to Author , Emily McDonald, Pallavi Annambhotla, Jason O. Velez, Janeen Laven, Amanda J. Panella, Kimberly D. Machesky, Jennifer L. White, Judie Hyun, Emily Freuck, Janice Habel, David Oh, Marilyn Levi, Rick Hasz, Elling Eidbo, J. Erin Staples, Sridhar V. Basavaraju, and Carolyn V. Gould
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (R.A. Soto, E. McDonald, J.O. Velez, J. Laven, A.J. Panella, J.E. Staples, C.V. Gould); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.D. Annambhotla, S.V. Basavaraju); Ohio Department of Health, Columbus, Ohio, USA (K.D. Machesky); New York Department of Health, Albany, New York, USA (J.L. White); Maryland Department of Health, Baltimore, Maryland, USA (J. Hyun); University of Cincinnati, Cincinnati, Ohio, USA (E. Freuck, J. Habel, D. Oh); Health Resources and Services Administration, Rockville, Maryland, USA (M. Levi); Association of Organ Procurement Organizations, Vienna, Virginia, USA (R. Hasz, E. Eidbo)

Main Article

Table 1

West Nile virus test results for organ donor and recipients, United States*

Person Specimen DRT RNA IgM Neutralizing antibodies (titer)† IgG
Organ donor
Plasma −2 Detected

Liver recipient
Serum 0 ND ND ND
Serum 18 ND Detected Detected (1;2,560)
CSF 22 Detected

Kidney recipient Serum 15 Detected ND
CSF 18 Detected Detected
Serum 18 Detected Detected
Whole blood 18 Detected
Urine 18 Detected
Serum 25 ND Detected
Whole blood 25 Detected

*Blank cells indicate testing not performed. CSF, cerebrospinal fluid; DRT, day relative to transplantation; ND, not detected. †90% plaque reduction neutralization test result <10 is considered negative.

Main Article

Page created: November 03, 2021
Page updated: January 22, 2022
Page reviewed: January 22, 2022
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