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Volume 28, Number 2—February 2022
Dispatch

West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States

Raymond A. SotoComments to Author , Emily McDonald, Pallavi Annambhotla, Jason O. Velez, Janeen Laven, Amanda J. Panella, Kimberly D. Machesky, Jennifer L. White, Judie Hyun, Emily Freuck, Janice Habel, David Oh, Marilyn Levi, Rick Hasz, Elling Eidbo, J. Erin Staples, Sridhar V. Basavaraju, and Carolyn V. Gould
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (R.A. Soto, E. McDonald, J.O. Velez, J. Laven, A.J. Panella, J.E. Staples, C.V. Gould); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.D. Annambhotla, S.V. Basavaraju); Ohio Department of Health, Columbus, Ohio, USA (K.D. Machesky); New York Department of Health, Albany, New York, USA (J.L. White); Maryland Department of Health, Baltimore, Maryland, USA (J. Hyun); University of Cincinnati, Cincinnati, Ohio, USA (E. Freuck, J. Habel, D. Oh); Health Resources and Services Administration, Rockville, Maryland, USA (M. Levi); Association of Organ Procurement Organizations, Vienna, Virginia, USA (R. Hasz, E. Eidbo)

Main Article

Table 2

Reported WNV solid organ transplant transmission events, United States, 2002–2013*

Date Location Organ donor
 Organ recipient outcomes
WNV screening Archived serum sample test result
 Likely/proven source of infection No. infected/ total No. NID/no. infected No. deaths reported Ref
RNA IgM/IgG
2002 Aug
 Georgia
 No
 Detected
 ND/NR
 Blood transfusion
4/4
 3/4
 1
 (2)
2005 Aug
 New York, Pennsylvania
 No
 ND
 Detected/ detected
 Mosquito
3/4
 2/3
 2
 (4)
2008 Sep
 Louisiana
 No
 ND
 ND/ND
 Blood transfusion
1/1
 1/1
 0
 (5)
2009 Sep Italy No Detected NR Mosquito 1/1 0/1 0 (8)
California No Detected ND/ND Mosquito 1/1 1/1 0 (10)
Texas
 No
 Detected
 Detected/ equivocal
 Mosquito
1/3
 1/1
 0
 CDC, unpub. data
2010 Oct
 California
 No
 Detected
 ND/detected
 Mosquito
2/3
 1/2
 1
 (9)
2011 Aug
 Italy
 NAT negative
 ND
 Detected/ detected
 Mosquito
4/5
 2/4
 0
 (7)
2011, early fall
California
 No
 ND (detected in spleen and lymph node)
 Detected/ detected (neutralizing antibodies also detected, titer 1:160)
 Mosquito
4/4
 3/4
 2
 (11)
2013 NR NR NR NR NR NR/3 NR 0 (6)

*CDC, Centers for Disease Control and Prevention; ND, not detected; NAT, nucleic acid test; NID, neuroinvasive disease; NR, testing not reported; ref, reference; WNV, West Nile virus.

Main Article

Page created: November 03, 2021
Page updated: January 22, 2022
Page reviewed: January 22, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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