Volume 28, Number 4—April 2022
Research
Fatal Human Alphaherpesvirus 1 Infection in Free-Ranging Black-Tufted Marmosets in Anthropized Environments, Brazil, 2012–2019
Tais M. Wilson, Jana M. Ritter, Roosecelis B. Martines, Hannah A. Bullock, Pamela Fair, Kay W. Radford, Isabel L. Macêdo, Davi E.R. Sousa, Alexandra A.B. Gonçalves, Alessandro P. Romano, Pedro H.O. Passsos, Daniel G. Ramos, Gabriela R.T. Costa, Karina R.L.J. Cavalcante, Cristiano B. de Melo, Sherif R. Zaki, and Marcio B. Castro
Table 2
Histopathologic features found during necropsy of free-ranging black-tufted marmosets naturallly infected with human alphaherpesvirus 1, Brazil, 2012–2019
| Organ, finding | No. affected/total (%)* |
|---|---|
| Brain | 12/13 (92) |
| Inclusion bodies within neurons and glial cells | 12/12 (100) |
| Neuronal necrosis | 12/12 (100) |
| Mononuclear perivascular cuffs | 12/12 (100) |
| Neuronophagy | 11/12 (92) |
| Reactive gliosis | 11/12 (92) |
| Neuropil inflammation | |
| Mononuclear cells | 10/12 (83) |
| Neutrophils | 3/12 (25) |
| Intravascular leukocytosis | 9/12 (75) |
| Nonsuppurative meningitis | 9/12 (75) |
| Glial nodules | 5/12 (42) |
| Reactive neurovascular endothelium |
5/12 (42) |
| Tongue | 9/13 (69) |
| Acantholysis | 8/9 (89) |
| Epithelial ballooning degeneration | 8/9 (89) |
| Epithelial intranuclear inclusion bodies | 8/9 (89) |
| Subepithelial inflammation | 8/9 (89) |
| Epithelial necrosis | 5/9 (55) |
| Ulcer | 4/9 (44) |
| Syncytial cells |
2/9 (22) |
| Liver | 1/13 (8) |
| Hepatocellular coagulative necrosis | 1/1 (100) |
| Intranuclear viral inclusion bodies | 1/1 (100) |
| Multinucleated giant cells | 1/1 (100) |
*Denominators indicate numbers of animals for which information was available.
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