Natural History of and Dynamic Changes in Clinical Manifestation, Serology, and Treatment of Brucellosis, China
, Hongyan Liu1
, Qiran Zhang1
, Xiaobo Lu1
, Dan Li1
, Haocheng Zhang1
, Yan A. Wang, Rongjiong Zheng, Yi Zhang, Zhangfan Fu, Ke Lin, Chao Qiu, Yan O. Wang, Ye Gu
, Jingwen Ai
, and Wenhong Zhang
Author affiliations: National Medical Center for Infectious Disease, National Clinical Research Center for Aging and Medicine, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China (H. Wang, Q. Zhang, H. Zhang, Y. Zhang, Z. Fu, K. Lin, C. Qiu, J. Ai, W. Zhang); The Sixth People’s Hospital of Shenyang, Shenyang, China (H. Liu, D. Li, Y.A. Wang, Y.O. Wang, Y. Gu); Emergency Treatment and Innovation Center of Public Health Emergencies, Shenyang (H. Liu, D. Li, Y.A. Wang, Y.O. Wang, Y. Gu); Center for Infectious Diseases, the First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, China (X. Lu, R. Zheng); Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai (W. Zhang)
Figure 1. Dynamic characteristics of clinical manifestations in case-patients with acute and chronic brucellosis, China, 2014–2020. A) Natural symptom development with symptom duration <180 days (early stage) or >180 days (late stage) before patients received antibiotic therapy. B) Kaplan-Meier curve of symptomatic case-patients after treatment initiation.
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